Figure 2.

Venn diagram used for overlapping the altered gene expression pattern in the case of the three studied groups. Common and specific gene expression signatures for the three groups of HNSCC (head and neck squamous cell carcinomas) patients: non-smokers, ex-smokers, and smokers. (A) For the case of overexpressed genes, 20 common genes from non-smokers vs. smokers and ex-smokers vs. smokers, integrated as network using String, version 10.5) [19]; (B) The case of downregulated genes; (C) Heat maps for the expression level for the three HNSCC patient groups (current smokers, quitters, non-smokers), in dark blue being presented the downregulated genes and in red those overexpressed genes, generated using Gene Spring version 13.0.