Table 1.
Succinct presentation of the TCGA characteristics for patients diagnosed with HNSCCs used for gene expression analysis. Head and neck squamous cell carcinomas: HNSCCs, T: tumor, N: node, M0 no metastasis, Mx: metastases presence; HPV: human papilloma virus; TCGA: The Cancer Genome Atlas.
| Clinical Parameters | Patients (n = 519) | Females/Males | |
|---|---|---|---|
| Sex | Females | 134 | |
| Males | 374 | ||
| Undeclared | 11 | ||
| Age | Median, range | 61, 19–90 | |
| Median, range males | 59, 19–88 | ||
| Median, range females | 64.5, 24–90 | ||
| Undeclared | 11 | ||
| Clinical stage | 1 | 20 | 9/11 |
| 2 | 98 | 33/65 | |
| 3 | 101 | 26/75 | |
| 4 | 275 | 64/211 | |
| Unknown | 25 | ||
| Clinical TNM | T1N0M0 | 18 | 7/11 |
| T1N1M0 | 5 | 2/3 | |
| T1N2M0 | 7 | 1/6 | |
| T1N2M1 | 1 | -/1 | |
| T1NxM0 | 2 | 2/- | |
| T1N0M0 | 96 | 33/63 | |
| T1N0Mx | 1 | -/1 | |
| T2N1M0 | 12 | 3/9 | |
| T2N1Mx | 1 | 1/- | |
| T2N2M0 | 33 | 6/27 | |
| T2N2M1 | 1 | -/1 | |
| T2N2Mx | 3 | -/3 | |
| T1N3M0 | 1 | -/1 | |
| T2NxM0 | 1 | -/1 | |
| T3N0M0 | 58 | 15/43 | |
| T3N0Mx | 1 | 1/- | |
| T2N1M0 | 20 | 4/16 | |
| T3N1M1 | 1 | 1/- | |
| T3N2M0 | 46 | 8/38 | |
| T3N2M1 | 1 | 1/- | |
| T3N2Mx | 1 | -/1 | |
| T3N3M0 | 1 | -/1 | |
| T3NxM0 | 2 | -/2 | |
| T4N0M0 | 66 | 17/49 | |
| T4N0Mx | 1 | 1/- | |
| T4N1M0 | 39 | 13/26 | |
| T4N2M0 | 62 | 14/48 | |
| T4N2Mx | 1 | -/1 | |
| T4N3M0 | 7 | 2/5 | |
| T4NxM0 | 3 | -/3 | |
| TxN1M0 | 1 | -/1 | |
| TxN2M0 | 1 | -/1 | |
| TxNxMx | 9 | -/9 | |
| Unknown | 16 | ||
| Smoking history | Smoker | 174 | 35/139 |
| Reformed smoker <15 years | 134 | 26/108 | |
| Reformed smoker >15 years | 72 | 19/53 | |
| Reformed, unknown years | 2 | 0/2 | |
| Lifelong non-smoker | 114 | 49/65 | |
| Unknown | 23 | ||
| Anatomic neoplasm subdivision | Alveolar ridge | 18 | |
| Base of tongue | 27 | ||
| Buccal mucosa | 20 | ||
| Floor of mouth | 60 | ||
| Hard palate | 7 | ||
| Hypopharynx | 9 | ||
| Larynx | 114 | ||
| Lip | 3 | ||
| Oral cavity | 71 | ||
| Oral tongue | 127 | ||
| Oropharynx | 10 | ||
| Tonsil | 42 | ||
| Unknown | 11 | ||
| HPV | Positive | 72 | |
| Negative | 37 | ||
| Unknown | 410 |