Table 2.

Genes with altered expression levels, based on a fold change (FC) ± 2, p-value ≤ 0.05 for smoking versus never smoking HNSCC patients.

Gene	FC (abs)	p-Value	Regulation	Gene	FC (abs)	p-Value	Regulation
CDKN2A	−2.59737	0.000603	Down	EPHA7	2.39461	0.000111	Up
RYR3	−2.35924	1.45 × 10−6	Down	psiTPTE22	2.394392	6.22 × 10−6	Up
KRT2	−2.31761	0.002097	Down	POU6F2	2.393242	3.2 × 10−6	Up
KCNS1	−2.31495	0.000321	Down	SOHLH1	2.390684	0.000256	Up
MYBPC1	−2.10091	0.046549	Down	LTF	2.380863	0.012372	Up
ARL14	−2.08283	0.000138	Down	MLXIPL	2.373807	8 × 10−6	Up
IL13RA2	−2.05906	8.82 × 10−5	Down	GLI2	2.372254	6.52 × 10−7	Up
FLRT3	−2.02315	0.002341	Down	NLGN4Y	2.358872	0.00092	Up
PLA2G2F	−2.01307	0.002746	Down	PAK7	2.355639	6.22 × 10−6	Up
NTS	5.224654	8 × 10−6	Up	FIBCD1	2.345015	0.000181	Up
RPS4Y1	4.924049	7.27 × 10−5	Up	GATA4	2.343389	0.000117	Up
UGT1A6	4.505707	3.3 × 10−7	Up	PANX2	2.319508	1.31 × 10−6	Up
UPK1B	4.336869	4.15 × 10−5	Up	PCYT1B	2.314619	3.29 × 10−5	Up
MGST1	4.296636	4.68 × 10−7	Up	FGF19	2.31125	3.18 × 10−5	Up
CYP1A1	4.269958	5.3 × 10−13	Up	SLC44A4	2.29202	0.000356	Up
C20orf114	3.985658	0.001123	Up	SCN2A	2.28985	0.00011	Up
SCGB3A1	3.985451	3.93 × 10−5	Up	PROM1	2.2842	0.001556	Up
GPR15	3.913692	2.69 × 10−15	Up	CYorf15A	2.257771	0.002582	Up
DDX3Y	3.748438	0.000214	Up	TFPI2	2.25193	0.000222	Up
MUC5B	3.573662	0.001207	Up	MSI1	2.249305	2.06 × 10−5	Up
CNNM1	3.508977	3.02 × 10−8	Up	ADD2	2.237741	6.45 × 10−5	Up
CES1	3.41544	1.21 × 10−5	Up	ALDH1A1	2.234898	0.000377	Up
PRAME	3.289014	0.000277	Up	ERN2	2.210954	0.000992	Up
GPX2	3.252181	3.95 × 10−6	Up	LGI3	2.206128	0.000183	Up
CYP26A1	3.241253	2.07 × 10−5	Up	PRKY	2.206114	0.002395	Up
NR5A1	3.186291	1.24 × 10−5	Up	SALL1	2.200458	8.32 × 10−6	Up
PPP1R1B	3.18047	1.38 × 10−5	Up	TBX5	2.194891	8.95 × 10−6	Up
FGFBP2	3.156294	2.95 × 10−6	Up	HOXA4	2.181679	4.15 × 10−6	Up
SLC13A5	3.142512	6.04 × 10−6	Up	TNNI3	2.18105	4.06 × 10−5	Up
DMBT1	3.102893	0.000721	Up	PLUNC	2.179797	0.009085	Up
KRTCAP3	3.077278	7.92 × 10−12	Up	NGB	2.177274	0.000323	Up
BPIL1	3.011847	0.002582	Up	FOLR1	2.175127	0.000402	Up
UGT1A8	3.00819	1.43 × 10−5	Up	GDA	2.163271	0.00378	Up
PTH2R	2.849531	2.55 × 10−5	Up	AKR1C3	2.150982	8.66 × 10−5	Up
KRT19	2.812564	0.001704	Up	AZGP1	2.142351	0.004176	Up
GAL	2.792954	6.04 × 10−6	Up	CCNA1	2.138528	0.001642	Up
EIF1AY	2.761805	0.001147	Up	PCDH19	2.131033	0.000887	Up
WNK2	2.756387	3.74 × 10−5	Up	GJB7	2.128482	0.000382	Up
B4GALNT4	2.731352	5.73 × 10−7	Up	WDR72	2.119921	0.003053	Up
RAB3B	2.721629	2.09 × 10−7	Up	CLDN8	2.118758	0.001164	Up
FAM132A	2.67193	2.95 × 10−6	Up	CBS	2.117995	2.03 × 10−5	Up
HOXA7	2.666479	3.29 × 10−5	Up	MSMB	2.117211	0.003146	Up
PIGR	2.652387	0.004096	Up	CFTR	2.112852	0.00034	Up
BCHE	2.639082	3.2 × 10−6	Up	NTRK2	2.112379	0.001737	Up
UGT8	2.635306	5.71 × 10−5	Up	FGF13	2.108137	2.2 × 10−5	Up
USP9Y	2.629508	0.001642	Up	RPL39L	2.085114	5.8 × 10−6	Up
PDIA2	2.613751	2.12 × 10−6	Up	SLC29A4	2.079458	4.68 × 10−7	Up
ZFY	2.558155	0.0013	Up	ADH7	2.07414	0.012696	Up
CALB1	2.545223	0.002413	Up	PIWIL2	2.068965	0.000399	Up
AKR1C1	2.540783	7.2 × 10−6	Up	CYP1B1	2.057724	8.81 × 10−5	Up
UTY	2.533913	0.00193	Up	CPNE7	2.055357	1.57 × 10−6	Up
ATP13A5	2.530633	0.00011	Up	BRDT	2.041222	0.001179	Up
SLC5A12	2.504015	2.95 × 10−6	Up	CHGA	2.033392	2.12 × 10−5	Up
FOXJ1	2.491234	0.000516	Up	ABO	2.032663	0.001283	Up
PRDM13	2.479601	4.03 × 10−7	Up	STATH	2.023424	0.020511	Up
HORMAD1	2.437306	0.001219	Up	SCN9A	2.018196	0.00048	Up
UCHL1	2.434416	7.96 × 10−6	Up	ADAMTS20	2.011134	0.000245	Up
NPW	2.41423	6.04 × 10−6	Up	RBM11	2.010622	4.12 × 10−5	Up
PNCK	2.396283	8.83 × 10−5	Up	ZNF556	2.009657	1.24 × 10−5	Up
				TCF15	2.007499	4.31 × 10−5	Up