Table 3.

Gene ontology (GO) classification based on the gene expression signature in smoking versus never-smoking HNSCC patients using the PantherDB online tool [21].

Ontology Function	Type	No. Molecules	Percent (%)
Molecular function	binding (GO:0005488)	33	36.7%
	catalytic activity (GO:0003824)	30	33.3%
	transporter activity (GO:0005215)	14	15.6%
	receptor activity (GO:0004872)	4	4.4%
	signal transducer activity (GO:0004871)	4	4.4%
	structural molecule activity (GO:0005198)	3	3.3%
	translation regulator activity (GO:0045182)	1	1.1%
	antioxidant activity (GO:0016209)	1	1.1%
Biological process	cellular process (GO:0009987)	48	28.1%
	metabolic process (GO:0008152)	32	18.7%
	biological regulation (GO:0065007)	23	13.5%
	developmental process (GO:0032502)	16	9.4%
	response to stimulus (GO:0050896)	15	8.8%
	multicellular organismal process (GO:0032501)	13	7.6%
	localization (GO:0051179)	8	4.7%
	cellular component organization or biogenesis (GO:0071840)	7	4.1%
	biological adhesion (GO:0022610)	4	2.3%
	locomotion (GO:0040011)	3	1.8%
	immune system process (GO:0002376)	1	0.6%
	reproduction (GO:0000003)	1	0.6%
Protein class	transporter (PC00227)	10	13.5%
	hydrolase (PC00121)	9	12.2%
	oxidoreductase (PC00176)	8	10.8%
	transcription factor (PC00218)	8	10.8%
	nucleic acid binding (PC00171)	7	9.5%
	signaling molecule (PC00207)	6	8.1%
	transferase (PC00220)	5	6.8%
	enzyme modulator (PC00095)	5	6.8%
	receptor (PC00197)	3	4.1%
	extracellular matrix protein (PC00102)	2	2.7%
	cytoskeletal protein (PC00085)	2	2.7%
	transfer/carrier protein (PC00219)	2	2.7%
	cell junction protein (PC00070)	2	2.7%
	lyase (PC00144)	1	1.4%
	calcium-binding protein (PC00060)	1	1.4%
	defense/immunity protein (PC00090)	1	1.4%
	membrane traffic protein (PC00150)	1	1.4%
	isomerase (PC00135)	1	1.4%