Table 4.
Gene ontology (GO) classification based on the gene expression signature in smoking versus never smoking for stage 1 HNSCC patients using the PantherDB online tool, showing the maximum effect of smoking and the minimum effect of tumor environment.
| Ontology Function | Type | No. Molecules | Percent (%) |
|---|---|---|---|
| Molecular function | binding (GO:0005488) | 1433 | 37.5% |
| catalytic activity (GO:0003824) | 1262 | 33.0% | |
| transporter activity (GO:0005215) | 429 | 11.2% | |
| receptor activity (GO:0004872) | 255 | 6.7% | |
| signal transducer activity (GO:0004871) | 231 | 6.0% | |
| structural molecule activity (GO:0005198) | 157 | 4.1% | |
| antioxidant activity (GO:0016209) | 23 | 0.6% | |
| translation regulator activity (GO:0045182) | 17 | 0.4% | |
| channel regulator activity (GO:0016247) | 13 | 0.3% | |
| Biological process | cellular process (GO:0009987) | 2479 | 29.5% |
| metabolic process (GO:0008152) | 1589 | 18.9% | |
| biological regulation (GO:0065007) | 911 | 10.9% | |
| response to stimulus (GO:0050896) | 696 | 8.3% | |
| localization (GO:0051179) | 583 | 6.9% | |
| cellular component organization or biogenesis (GO:0071840) | 581 | 6.9% | |
| developmental process (GO:0032502) | 534 | 6.4% | |
| multicellular organismal process (GO:0032501) | 523 | 6.2% | |
| immune system process (GO:0002376) | 146 | 1.7% | |
| locomotion (GO:0040011) | 120 | 1.4% | |
| biological adhesion (GO:0022610) | 110 | 1.3% | |
| reproduction (GO:0000003) | 83 | 1.0% | |
| rhythmic process (GO:0048511) | 32 | 0.4% | |
| cell killing (GO:0001906) | 6 | 0.1% | |
| Protein class | nucleic acid binding (PC00171) | 565 | 15.2% |
| transcription factor (PC00218) | 504 | 13.5% | |
| hydrolase (PC00121) | 410 | 11.0% | |
| receptor (PC00197) | 355 | 9.5% | |
| transporter (PC00227) | 269 | 7.2% | |
| signaling molecule (PC00207) | 251 | 6.7% | |
| transferase (PC00220) | 240 | 6.4% | |
| cytoskeletal protein (PC00085) | 192 | 5.2% | |
| enzyme modulator (PC00095) | 179 | 4.8% | |
| oxidoreductase (PC00176) | 149 | 4.0% | |
| extracellular matrix protein (PC00102) | 84 | 2.3% | |
| membrane traffic protein (PC00150) | 83 | 2.2% | |
| ligase (PC00142) | 79 | 2.1% | |
| calcium-binding protein (PC00060) | 72 | 1.9% | |
| structural protein (PC00211) | 63 | 1.7% | |
| isomerase (PC00135) | 42 | 1.1% | |
| lyase (PC00144) | 36 | 1.0% | |
| defense/immunity protein (PC00090) | 35 | 0.9% | |
| cell adhesion molecule (PC00069) | 31 | 0.8% | |
| cell junction protein (PC00070) | 31 | 0.8% | |
| chaperone (PC00072) | 24 | 0.6% | |
| transfer/carrier protein (PC00219) | 19 | 0.5% | |
| transmembrane receptor regulatory/adaptor protein (PC00226) | 11 | 0.3% |