Table 5.
Gene ontology (GO) classification based on the gene expression signature in HPV16-positive versus HPV16-negative patients using the PantherDB online tool [21].
| Ontology Function | Type | No. Molecules | Percent (%) |
|---|---|---|---|
| Molecular function | binding (GO:0005488) | 6900 | 41.1% |
| catalytic activity (GO:0003824) | 5156 | 30.7% | |
| transporter activity (GO:0005215) | 1474 | 8.8% | |
| receptor activity (GO:0004872) | 1450 | 8.6% | |
| signal transducer activity (GO:0004871) | 895 | 5.3% | |
| structural molecule activity (GO:0005198) | 826 | 4.9% | |
| translation regulator activity (GO:0045182) | 53 | 0.3% | |
| antioxidant activity (GO:0016209) | 23 | 0.1% | |
| binding (GO:0005488) | 6900 | 41.1% | |
| Biological process | cellular process (GO:0009987) | 10968 | 28.1% |
| metabolic process (GO:0008152) | 6589 | 16.9% | |
| biological regulation (GO:0065007) | 4065 | 10.4% | |
| response to stimulus (GO:0050896) | 3467 | 8.9% | |
| developmental process (GO:0032502) | 3319 | 8.5% | |
| multicellular organismal process (GO:0032501) | 2954 | 7.6% | |
| cellular component organization or biogenesis (GO:0071840) | 2626 | 6.7% | |
| localization (GO:0051179) | 2125 | 5.4% | |
| immune system process (GO:0002376) | 975 | 2.5% | |
| biological adhesion (GO:0022610) | 898 | 2.3% | |
| locomotion (GO:0040011) | 668 | 1.7% | |
| reproduction (GO:0000003) | 289 | 0.7% | |
| rhythmic process (GO:0048511) | 28 | 0.1% | |
| growth (GO:0040007) | 27 | 0.1% | |
| Protein class | hydrolase (PC00121) | 2235 | 13.2% |
| nucleic acid binding (PC00171) | 1676 | 9.9% | |
| signaling molecule (PC00207) | 1598 | 9.5% | |
| transcription factor (PC00218) | 1551 | 9.2% | |
| enzyme modulator (PC00095) | 1462 | 8.7% | |
| receptor (PC00197) | 1324 | 7.8% | |
| cytoskeletal protein (PC00085) | 987 | 5.9% | |
| transferase (PC00220) | 987 | 5.9% | |
| transporter (PC00227) | 977 | 5.8% | |
| oxidoreductase (PC00176) | 667 | 4.0% | |
| extracellular matrix protein (PC00102) | 632 | 3.7% | |
| cell adhesion molecule (PC00069) | 560 | 3.3% | |
| calcium-binding protein (PC00060) | 362 | 2.1% | |
| membrane traffic protein (PC00150) | 331 | 2.0% | |
| cell junction protein (PC00070) | 307 | 1.8% | |
| defense/immunity protein (PC00090) | 278 | 1.6% | |
| ligase (PC00142) | 185 | 1.1% | |
| structural protein (PC00211) | 173 | 1.0% | |
| chaperone (PC00072) | 157 | 0.9% | |
| transmembrane receptor regulatory/adaptor protein (PC00226) | 147 | 0.9% | |
| lyase (PC00144) | 134 | 0.8% | |
| isomerase (PC00135) | 66 | 0.4% | |
| transfer/carrier protein (PC00219) | 63 | 0.4% |