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. 2018 Jul 31;92(16):e00949-18. doi: 10.1128/JVI.00949-18

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FIG 5 — Crystal structure of the 701-F02 Fab/VN/04 HA complex. (A) Overview of the 70-1F02 FAb/H5 complex structure. Ribbons represent a single HA trimer bound to three 70-1F02 FAbs. For clarity, a single HA1 protomer and a single HA2 protomer are colored in magenta and cyan, respectively, with the 70-1F02 FAb heavy and light chains colored in green and blue, respectively. N-carbohydrates are indicated as yellow sticks. (B) The Ab 70-1F02 epitope on H5 HA. Residues on A/Vietnam/1203/2004 (H5N1) HA contacted by 70-1F02 are indicated. The primarily component of the epitope is the helical strand of the HA2 (11 residues). Residues within the 70-1F02 epitope are indicated as sticks on a ribbon representation of the H5 HA. Contact residues in the HA1 and HA2 subdomains are colored in magenta (HA1) and cyan (HA2), respectively. The epitope spans the two HA1 and HA2 subunits in a single HA trimer and does not contact the subunits of adjacent monomers. Residues are numbered consecutively, according to the mature protein.