FIG 11.

Summary of amino acid substitutions in Env present at ≥10% frequencies in acute phase samples from four group 2 controllers. Each substitution is enclosed by a square, and its details are listed in a text box outside the Env main sequence. The details provided for each amino acid substitution include the animal identifier (ID), time point postinfection, position in the Env protein, and the frequency of sequence reads displaying the wild-type (boldface type) and mutant residues. As a reference, several topological features of the SIV Env protein are shown, including the five variable loops (V) in gp120, the gp120/gp41 cleavage site, the membrane spanning domain, and the highly immunogenic region of gp41. The location of the Mamu-B*17-restricted Env FW9 epitope is also indicated in the carboxyl terminus of gp41.