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Viral PAMPs exposed by PF74 treatment are sensed by cGAS. Viral luciferase activity (A) and ISRE activity (B) was determined at 48 hpi in THP-1 cells and cGAS KO THP-1 cells treated with dimethyl sulfoxide (DMSO) or 10 μM PF74. The results represent means and standard deviations of technical triplicates from one of three independent experiments.
