TABLE 4.

Summary of population metrics

Protease	No. of bases sequenced	No. (%) of mutations detected	Diversity (p distance)			Sn valuea
			Sequence	Synonymous	Nonsynonymous
WTp1	8.8 × 106	2,691 (0.03)	0.00047 ± 0.00000	0	0.00062 ± 0.00001	0.04
MAXp1	8.5 × 106	4,257 (0.05)	0.00085 ± 0.00004	0	0.00113 ± 0.00006	0.05
WTp32	7.2 × 106	2,465 (0.03)	0.00057 ± 0.00001	0.00053 ± 0.00002	0.00061 ± 0.00001	0.05
MAXp32	5.2 × 106	2,924 (0.06)	0.00095 ± 0.00001	0.000310 ± 0.00002	0.00117 ± 0.00001	0.06
WTp32 ATV	1.9 × 107	71,206 (0.37)	0.00517 ± 0.00004	0.00016 ± 0.00001	0.0067 ± 0.00003	0.2
MAXp32 ATV	2.5 × 107	180,514 (0.73)	0.00946 ± 0.00005	0.000356 ± 0.00001	0.01252 ± 0.00005	0.27
WTp32 DRV	4.1 × 107	148,066 (0.36)	0.00482 ± 0.00003	0.00016 ± 0.00001	0.00624 ± 0.00003	0.16
MAXp32 DRV	1.9 × 107	95,202 (0.73)	0.00490 ± 0.00004	0.00026 ± 0.00001	0.00756 ± 0.00004	0.17

^aShannon's entropy value.