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. 2018 Jul 31;92(16):e00593-18. doi: 10.1128/JVI.00593-18

TABLE 3.

Nluc reporter gene stability of rPB2-MA9/PA-D479N after passage

Mouse Retention of Nluc activity (no. of plaques/total)
C1M1a C6M1b C1A5M1c
1 9/9 10/10 10/10
2 10/10 10/10 10/10
3 10/10 10/10 10/10
4 10/10 10/10 10/10
5 10/10 10/10 10/10
a

One passage in MDCK cells and 4 days of infection in DBA/2 mice.

b

Six passages in MDCK cells and 4 days of infection in DBA/2 mice.

c

One passage in MDCK cells, 5 passages in A549 cells, and 4 days of infection in DBA/2 mice.