FIG 4.
Therapeutic efficacies of LP-50 and LP-51 in acute SHIV infection. (A to C) Starting from day 11 after virus inoculation, 15 SHIVSF162P3-infected rhesus monkeys were subcutaneously treated with normal saline (A), LP-50 (B), or LP-51 (C) once daily for 4 weeks. The plasma viral loads of monkeys were measured at different time points by quantitative PCR. (D) Comparison of the viral load kinetics in monkeys treated with LP-50, LP-51, and normal saline control. A Mann-Whitney U test was performed to judge the significance of the differences during treatment (P, 0.0009 for LP-50 versus saline; P, 0.0006 for LP-51 versus saline; P, 0.3796 for LP-50 versus LP-51).