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Mutations alter sensitivity to inhibition by mCD4. Shown are data for sCD4 mimetic M48-U1 inhibition of pseudoviruses bearing WT Env or culture 1 to culture 4 [C1 to C4] N44-resistant Envs (A), Envs with gp41 mutations (B), Envs with pathway 1 gp120 mutations (C), and Envs with pathway 2 gp120 mutations (D). Data points are the averages of results from at least two independent experiments, each conducted in duplicate. Error bars show standard errors of the means (SEM).
