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. 2018 Jul 31;92(16):e00938-18. doi: 10.1128/JVI.00938-18

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Copyright © 2018 Marín-López et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — MVA-NS1-Nt protects against BTV-4, while MVA-NS1-Ct fails to confer protection in IFNAR^−/− mice. (A and D) Survival rates of mice immunized with MVA-NS1-Ct (A) and MVA-NS1-Nt (D) after infection with a lethal dose of BTV-4. Animals were inoculated with 10⁷ PFU following a prime-boost strategy. (B) Viral titers of BTV-4 recovered in blood from control and MVA-NS1-Ct-immunized IFNAR^−/− mice after challenge. (C and E) Postchallenge sickness scores of mice immunized with MVA-NS1-Ct (C) and MVA-NS1-Nt (E).