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. 2018 Jul 31;37:177. doi: 10.1186/s13046-018-0822-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Schematic illustration the relevance among circ-IARS, miR-122, ZO-1, and RhoA expression. Circ-IARS competitively adsorbed miR-122, inhibited its expression and relieved its inhibition of downstream target gene RhoA activity, increased the activity of RhoA, increased the expression of F-actin, and promoted cell contraction. In addition, the increase of RhoA activity reduced the expression of ZO-1 and disrupted the tight junction between the endothelium, which eventually led to the increase of vascular endothelial permeability and promotes tumor metastasis