Table 3.
Characteristics of large molecular clusters resulting from combined 15-MIRU and spoligotyping cluster analysis.
| Number | Cluster codea | Number of cases in cluster | Sex, male: female | Median age (IQR) | Diagnosis lapseb (months) | Same residential districtc | Known risk factor (number)d | Lineage (sub-lineage) | Drug resistancee |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MSC4063.X | 35 | 31:4 | 34 (26–44) | 40 | 7/5/5/4/4/5 | Smoking (6) Other (8) |
L4 (Cameroon) | 3 |
| 2 | MSC4060.X | 34 | 24:10 | 34 (25–45) | 41 | 6/4/3/3/3/3 | Smoking (6) Other (5) |
L4 (Cameroon) | 4 |
| 3 | MSC4045.X | 30 | 26:4 | 40 (29–48) | 39 | 7/3/3/3/3 | Smoking (5) HIV (4) Other (3) |
L4 (Cameroon) | 2 |
| 4 | MSC2001 | 27 | 22:5 | 35 (27–48) | 37 | 8/5 | Smoking (8) HIV (4) Other (2) |
L2 (Beijing) | 1 |
| 5 | MSC4031 | 26 | 19:7 | 41 (33–52) | 36 | 6/4/3 | Smoking (6) HIV (3) Other (1) |
L4 (Ghana) | 11 |
| 6 | MSC4110 | 26 | 21:5 | 38 (28–51) | 39 | 6/3 | Smoking (5) HIV (1) Other (4) |
L4 (Ghana) | ND |
| 7 | MSC4095 | 24 | 16:8 | 35 (24–45) | 39 | 7/6 | Smoking (5) Other (2) |
L4 (Ghana) | 9 |
| 8 | MSC4027 | 21 | 16:5 | 27 (25–45) | 40 | 6/3 | Smoking (3) | L4 (Ghana) | 3 |
| 9 | MSC4063.3 | 19 | 18:1 | 28 (21–45) | 41 | 5/5 | Smoking (7) | L4 (Cameroon) | ND |
| 10 | MSC4063.18 | 18 | 10:7 | 35 (24–41) | 36 | 6/3 | Smoking (4) HIV (1) |
L4 (Cameroon) | ND |
| 11 | MSC4013 | 15 | 13:2 | 42 (32–55) | 32 | 4/3 | Smoking (3) HIV (2) Other (2) |
L4 (Haarlem) | 2 |
| 12 | MSC4136 | 15 | 13:2 | 36 (28–44) | 34 | 6 | Smoking (2) HIV (1) Other (3) |
L4 (Haarlem) | ND |
| 13 | MSC4040 | 14 | 8:6 | 31 (27–45) | 33 | 3/3 | HIV (1) Other (4) |
L4 (Cameroon) | 1 |
| 14 | MSC4069.X | 14 | 11:3 | 27 (23–38) | 34 | 6/3 | Smoking (2) HIV (2) Other (1) |
L4 (Cameroon) | ND |
| 15 | MSC4073 | 14 | 9:5 | 40 (29–47) | 24 | 5/4 | Smoking (3) | L4 (Cameroon) | 3 |
| 16 | MSC5002.X | 14 | 7:7 | 40 (38–53) | 28 | 5 | HIV (2) Smoking (1) |
L5 (West African I) | 2 |
| 17 | MSC4063.2 | 13 | 8:4 | 37 (27–44) | 38 | 4 | Smoking (2) Other (3) |
L4 (Cameroon) | ND |
| 18 | MSC4068.X | 13 | 9:4 | 35 (30–44) | 27 | 5/3 | Smoking (6) HIV (2) Other (2) |
L4 (Cameroon) | ND |
| 19 | MSC4024 | 12 | 6:5 | 28 (26–42) | 37 | 3 | Smoking (2) Other (1) |
L4 (X3) | 4 |
| 20 | MSC4060.18 | 12 | 7:5 | 35 (32–40) | 36 | 3/3 | Smoking (2) HIV (2) Other (3) |
L4 (Cameroon) | 1 |
| 21 | MSC4063.17 | 12 | 7:5 | 26 (24–51) | 39 | ND | Smoking (4) HIV (1) Other (3) |
L4 (Cameroon) | 2 |
| 22 | MSC4138 | 11 | 7:4 | 41 (30–48) | 28 | 4 | Smoking (4) | L4 (LAM) | ND |
| 23 | MSC4069.3 | 10 | 5:5 | 32 (24–39) | 31 | 3 | Smoking (1) HIV (1) |
L4 (Cameroon) | 2 |
| 24 | MSC4104 | 10 | 7:2 | 35 (25–54) | 34 | 5 | Smoking (3) Other (1) |
L4 (Ghana) | 6 |
| 25 | MSC6006 | 10 | 4:6 | 41 (35–47) | 33 | 5/3 | Smoking (1) Other (2) |
L6 (West African II) | ND |
| 26 | MSC4045.3 | 9 | 7:2 | 43 (32–50) | 33 | 3 | Smoking (1) Other (1) |
L4 (Cameroon) | 1 |
| 27 | MSC4060.21 | 9 | 6:3 | 32 (26–43) | 22 | ND | HIV (1) Other (2) |
L4 (Cameroon) | ND |
| 28 | MSC4060.3 | 9 | 5:4 | 32 (25–53) | 34 | 3 | Smoking (1) Other (2) |
L4 (Cameroon) | ND |
| 29 | MSC4193 | 9 | 9:0 | 36 (30–41) | 28 | ND | Smoking (6) HIV (1) Other (2) |
L4 (Cameroon) | ND |
| 30 | MSC4068.3 | 8 | 6:2 | 45 (34–54) | 27 | 2 | Smoking (2) HIV (1) Other (1) |
L4 (Cameroon) | ND |
| 31 | MSC4022 | 7 | 6:1 | 50 (46–62) | 36 | 4 | Smoking (1) Other (1) |
L4 (Haarlem) | ND |
| 32 | MSC4060.4 | 7 | 3:4 | 34 (30–49) | 22 | 5 | Smoking (1) | L4 (Cameroon) | ND |
| 33 | MSC4080.13 | 7 | 4:3 | 24 (17–50) | 20 | 3 | Smoking (1) | L4 (Cameroon) | 1 |
| 34 | MSC4082 | 7 | 6:1 | 35 (28–40) | 33 | 3 | Smoking (1) | L4 (Ghana) | ND |
| 35 | MSC4107 | 7 | 7:0 | 38 (29–53) | 28 | 3/3 | Smoking (2) Other (1) |
L4 (Ghana) | 1 |
| 36 | MSC5003.2 | 7 | 4:3 | 35 (26–57) | 33 | ND | HIV (1) | L5 (West African I) | 1 |
| 37 | MSC5003.X | 7 | 7:0 | 43 (26–66) | 34 | 3 | Smoking (2) Other (1) |
L5 (West African I) | ND |
| 38 | MSC6004 | 7 | 5:2 | 44 (36–50) | 31 | ND | HIV (1) Other (3) |
L6 (West African II) | 3 |
MIRU, mycobacterial interspersed repetitive unit; L2, lineage 2; L4, lineage 4; L5, lineage 5; L6, lineage 6; ND, none determined; IQR, interquartile range.
Cluster codes in bold font involved evidence of household transmission.
Time lapse (in months) between first diagnosed case and last diagnosed case.
Number of participants with the same district of residence. Only >2 individuals in the same residential district are indicated. ‘/’ is used to separate individuals from different districts.
‘Other’ in this category refers to alcohol or substance abuse.
Number of participants carrying strains with drug resistance to either isoniazid or rifampicin.