Table 4.
Plasmodium falciparum parasite densities in patients with severe malaria and loci included in the univariate analysis
| Patients (n) | Parasite density per μL | p value* | |
|---|---|---|---|
| ATP2B4 (rs1541255) | |||
| Normal (AA) | 989 | 43 540 (37 370–50 729) | .. |
| Heterozygous (AG) | 1005 | 40 027 (34 396–46 579) | 0·72 |
| Homozygous (GG) | 181 | 28 635 (20 033–40 929) | 0·04 |
| IL10 (rs1800890) | |||
| Normal (AA) | 1294 | 39 224 (34 329–44 817) | .. |
| Heterozygous (AT) | 808 | 42 156 (35 612–49 902) | 0·78 |
| Homozygous (TT) | 95 | 46 900 (28 675–76 707) | 0·77 |
| LPHN2 (also known as ADGRL2; rs72933304) | |||
| Normal (CC) | 1880 | 40 179 (35 962–44 890) | .. |
| Heterozygous (AC) | 292 | 42 316 (31 939–56 066) | 0·93 |
| Homozygous (AA) | 8 | 36 451 (6660–199 493) | 0·99 |
| LOC727982 (rs1371478) | |||
| Normal (CC) | 1065 | 40 204 (34 692–46 591) | .. |
| Heterozygous (CT) | 946 | 41 676 (35 640–48 734) | 0·94 |
| Homozygous (TT) | 162 | 34 272 (23 482–50 019) | 0·72 |
| ARL14 (rs75731597) | |||
| Normal (AA) | 1726 | 41 555 (37 009–46 660) | .. |
| Heterozygous (AC) | 394 | 34 628 (27 171–44 130) | 0·37 |
| Homozygous (CC) | 18 | 34 337 (11 042–106 776) | 0·94 |
| FREM3 (rs186873296) | |||
| Normal (AA) | 1933 | 41 607 (37 305–46 405) | .. |
| Heterozygous (AG) | 232 | 32 556 (23 759–44 611) | 0·31 |
| Homozygous (GG) | 5 | 119 644 (13 995–1 022 828) | 0·59 |
| INPP4B (rs77389579) | |||
| Normal (GG) | 1985 | 39 666 (35 611–44 182) | .. |
| Heterozygous (GT) | 186 | 48 607 (34 175–69 133) | 0·52 |
| Homozygous (TT) | 2 | 293 153 (9811–8 759 196) | 0·48 |
| ABO (rs8176719)† | |||
| Non-blood group O | 1161 | 46 170 (40 068–54 455) | .. |
| Blood group O | 1026 | 35 092 (30 220–40 749) | 0·02 |
| ABO (rs8176746)‡ | |||
| Normal (CC) | 1504 | 38 608 (34 118–43 688) | .. |
| Heterozygous (AC) | 613 | 44 829 (36 937–54 406) | 0·40 |
| Homozygous (AA) | 74 | 46 817 (26 814–81 739) | 0·78 |
| HBB (rs334) | |||
| Normal (AA) | 2125 | 42 857 (38 648–47 525) | .. |
| Heterozygous (AT) | 56 | 8649 (4575–16 350) | 3·66 × 10−6 |
| Homozygous (TT) | 11 | 8850 (2103–37 235) | 0·08 |
| RPS6KL1 (rs3742785) | |||
| Normal (CC) | 1015 | 42 920 (36 915–44 901) | .. |
| Heterozygous (AC) | 881 | 39 668 (33 743–46 633) | 0·76 |
| Homozygous (AA) | 185 | 44 458 (31 235–63 279) | 0·98 |
| HBA (α−3·7-thalassaemia) | |||
| Normal | 843 | 39 969 (33 877–47 157) | .. |
| Heterozygous | 1009 | 40 292 (34 639–46 867) | 0·99 |
| Homozygous | 257 | 38 243 (28 345–51 598) | 0·96 |
| CD40LG (rs3092945) | |||
| Normal (TT) | 1432 | 39 307 (34 627–44 619) | .. |
| Heterozygous (CT) | 383 | 44 242 (34 624–56 532) | 0·67 |
| Homozygous (CC) | 375 | 42 007 (32 789–53 815) | 0·88 |
| G6PD (rs1050828) | |||
| Normal (CC) | 1616 | 41 464 (36 808–46 708) | .. |
| Heterozygous (CT) | 301 | 41 157 (31 232–54 236) | 0·99 |
| Homozygous (TT) | 267 | 35 063 (26 158–47 000) | 0·55 |
Data are geometric mean (95% CI).
*
Adjusted for ethnicity, gender and rs334 genotype; for this subanalysis of parasite densities, we judged p<0·05 significant.
†
The rs8176719 polymorphism identifies blood group O in the homozygous deletion form.
‡
The derived allele of rs8176746 identifies blood group B.