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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Nature. 2017 Sep 13;549(7672):345–350. doi: 10.1038/nature23888

Extended Data Figure 10. GPe-PV neurons mediate their effects through SNr-GABA neurons.

Extended Data Figure 10

a, Procedure to test LMS and CPP during SNr-GABA activation. b, c, Activating SNr-GABA neurons with CNO prevented LMS (b; p = 0.010) and CPP (c; p = 0.015). d, Injection strategy to test if SNr-GABA neurons are downstream of GPe-PV neurons. e, f, While expression of Kir2.1 in GPe-PV neurons prevented LMS and CPP, this suppression was overcome by concurrent inhibition of SNr-GABA neurons (e; p = 0.035, f; p = 0.036). The schematics of the mouse brain in this figure were adapted from ref. 33.