Fig. 7.

Lipidomics Case Study: Marginal Assessment under the RFM. a Generalised volcano plots for each explanatory treatment term within the saturated model, where the term specific p-value has been adjusted via the corresponding one-way multiplicity correction under RFM and biological relevance is defined through the treatment mean square. b Heatmap of the term specific p-values (−log₁₀(p)) adjusted via the corresponding one-way multiplicity correction under RFM. Grey indicates an adjusted p-value < 0.05. C) Heatmap of the term specific p-values (−log₁₀(p)) for the extended contrast model adjusted via the corresponding one-way multiplicity correction under RFM. Grey indicates a non-significant adjusted p-value < 0.05