Table 3.
Subgroup analysis of pooled HRs for overall survival in patients with low PINX1 expression.
| Stratified analysis | No. of cohorts | No. of patients | Pooled HR (95.0% CI) | P value | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
| I 2 (%) | P value | Model | |||||
| Tumor type | |||||||
| Colorectal cancer | 2 | 169 | 2.28 (1.46 – 3.56) | <0.001 | 0.0 | 0.961 | Fixed |
| Non-small cell lung cancer | 3 | 302 | 1.48 (1.06 – 2.08) | 0.023 | 0.0 | 0.567 | Fixed |
| Other | 6 | 1,807 | 1.36 (0.74 – 2.50) | 0.931 | <0.001 | Random | |
| Sample size | |||||||
| ≤150 | 4 | 435 | 1.23 (0.52 – 2.88) | 0.635 | 94.5 | <0.001 | Random |
| >150 | 7 | 1,843 | 1.70 (1.15 – 2.50) | 0.007 | 88.2 | <0.001 | Random |
| Test method | |||||||
| IHC only | 6 | 568 | 1.34 (0.73 – 2.46) | 0.341 | 80.4 | <0.001 | Random |
| IHC + TMA | 5 | 1,710 | 1.72 (1.05 – 2.84) | 0.032 | 85 | <0.001 | Random |
| Cutoff value | |||||||
| Staining index ≤4 | 4 | 1,424 | 0.30 (-0.22 – 0.82) | 0.255 | 85.5 | <0.001 | Random |
| Stained cells <65.0% | 7 | 854 | 0.49 (-0.12 – 1.10) | 0.116 | 83.8 | <0.001 | Random |
| Type of analysis | |||||||
| Univariate | 7 | 851 | 1.61 (0.86 – 3.03) | 0.136 | 87.8 | <0.001 | Random |
| Multivariate | 4 | 1,427 | 1.40 (0.86 – 2.29) | 0.178 | 87.3 | <0.001 | Random |
| NOS score | |||||||
| ≤6 | 6 | 859 | 1.48 (0.83 – 2.65) | 0.186 | 84.7 | <0.001 | Random |
| >6 | 5 | 1,419 | 1.55 (0.87 – 2.74) | 0.134 | 84.9 | <0.001 | Random |
CI, confidence interval; HR, hazard ratio; IHC, immunohistochemistry; No., number; NOS, Newcastle-Ottawa Quality Assessment Scale; TMA, tissue microarray.