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. 2018 Jul 31;24:39. doi: 10.1186/s10020-018-0040-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Protective effects of IP and NRG-1 were suppressed by the ErbB4 inhibitor AG1478 ex vivo. (a), Representative heart slices stained by TTC, red: the ischaemic area, white: infarct area. (b), the percentage of infarct size/left ventricle (IS/LV%). (c), Histological analysis of heart sections in Langendorff model by hematoxylin and eosin staining. CON: control, IR: ischaemia-reperfusion, IP: ischaemic postconditioning, NRG-1: IR + NRG-1. Data are shown as the mean ± SEM (n = 6). *p < 0.05 vs. IR; #p < 0.05 vs. the same treated group without AG1478