REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
polyclonal rabbit anti-m6A (and m6Am)	Synaptic Systems	202 003; RRID: AB_2279214
polyclonal rabbit anti-METTL3	Proteintech	15073-1-AP; RRID: AB_2142033
monoclonal mouse anti-FTO	Merck Millipore	MABE227; RRID: AB_11203491
polyclonal rabbit anti-ACTB	Cell Signaling Technology	4967; RRID: AB_330288
monoclonal rabbit anti-GR	Abcam	ab109022; RRID: AB_10863164
polyclonal rabbit anti-BTUB	Abcam	ab6046; RRID: AB_2210370
Chemicals, Peptides, and Recombinant Proteins
corticosterone-HBC complex	Sigma	C174
Dexa-ratiopharm	Ratiopharm	Dexa-ratiopharm Injektionslösung 59988.00.00
cycloheximide	Sigma	C7698
Critical Commercial Assays
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)	Epigentek	P-9005-96
TruSeq Stranded mRNA Library Prep Kit	Illumina	RS-122-2103
TruSeq Ribo Profile for Mammalian	Illumina	RPHMR12126
QuantiFast SYBR Green PCR Kit	QIAGEN	204057
TaqMan Fast Advanced Master Mix	Applied Biosystem	4444965
Deposited Data
superseries	This paper	GEO: GSE113801
m6A/m-Seq mouse cortex after acute stress	This paper	GEO: GSE113781
Ribosome profiling Seq mouse cortex after acute stress	This paper	GEO: GSE113789
m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice	This paper	GEO: GSE113793
mRNA-Seq of mouse Mettl3 cKO or Fto cKO mouse hippocampus after fear conditioning	This paper	GEO: GSE113796
m6A/m-Seq of human B-lymphocyte cell lines from healthy controls and major depressive disorder patients	This paper	GEO: GSE113798
FMR1 bound genes	Darnell et al., 2011	Darnell et al., 2011 Supplemental Data
Experimental Models: Cell Lines
Human immortalized BLCLs from patients	This paper	N/A
Experimental Models: Organisms/Strains
10-12 w old adult male mice C57BL/6	Charles River	027
Mettl3 cKO mice	Mettl3tm1a(KOMP)Wtsi V6.5 mouse ESCs targeted as described in mice generated by Geula et al., 2015	Mettl3tm1c(KOMP)Wtsi
Fto cKO mice	Ftotm1a(EUCOMM)Wtsi EMMA EM: 05094	Ftotm1c(EUCOMM)Wtsi
Camk2a-Cre mice	Minichiello et al., 1999	Tg(Camk2a-cre)93Kln MGI:2176754
Nex-CreERT2 mice	Agarwal et al., 2012	Neurod6tm2.1(cre/ERT2)Kan MGI:5308766
Human blood	Menke et al., 2012, Arloth et al., 2015	“MPIP” and “MARS” cohorts
Oligonucleotides
Gene expression primers for SYBR green qPCR: sequences see Gene expression	Sigma-Aldrich	N/A
Taqman gene expression assays: IDs see Candidate m6A/m-RIP-qPCR	Taqman	N/A
m6A-spike-in-oligo GCAGAACCUAGUAG CGUGUGGm6ACACGAACAGGUAUCAAU AUGCGGGUAUGGm6ACUAAAGCAACGUG CGAGAUUACGCUGAGGm6ACUACAAUCU 'CAGUUACCA	Sigma-Aldrich	N/A
primers for cloning ISH probes: Mettl3 exon 4 TCAGTCAGGAGATCCTAGAGCTATT and CTGAAGTGCAGCTTGCGACA; Fto exon 4 TGGCAGCTGAAATACCCTAAACT and ATAG CTGTACACTGCCACGG)	Sigma-Aldrich	N/A
Software and Algorithms
STAR	Dobin et al., 2013	RRID: SCR_015899
cutadapt	Martin, 2011	RRID: SCR_011841
exomePeak	Meng et al., 2014	RRID: SCR_001076
BEDTools	Quinlan and Hall, 2010	RRID: SCR_006646
DiffBind	Ross-Innes et al., 2012	RRID: SCR_012918
DESeq2	Love et al., 2014	RRID: SCR_015687
ChIPseeker	Yu et al., 2015	https://doi.org/10.18129/B9.bioc.ChIPseeker
BioMart Project	Smedley et al., 2015	RRID: SCR_002987
Guitar	Cui et al., 2016	https://doi.org/10.18129/B9.bioc.Guitar
PANTHER GO	Mi et al., 2013	RRID: SCR_004869
DREME	Bailey, 2011	RRID: SCR_001783
Integrative Genomics Viewer browser	Robinson et al., 2011	RRID: SCR_011793
SPSS	IBM SPSS Statistics	RRID: SCR_002865
R	R Development Core Team, 2011	RRID: SCR_001905
ggplot2	Wickham, 2009	RRID: SCR_014601