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. 2018 Jul 31;10:74. doi: 10.1186/s13195-018-0402-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Chromatography, model compartmentalization, and data fit of [¹⁸F]MK-6240. a Chromatogram showing parent compound and metabolite of [¹⁸F]MK-6240 in counts per minute (cpm) for representative AD participant. b Reversible two-tissue compartment model with four parameters (2T-CM4k) fit in time–activity curves from posterior cingulate (PCC), temporal, and anterior cingulate (ACC) cortices, as well as cerebellar gray matter (GM) of representative mild cognitive impairment (MCI) individual. c Logan graphical plot became linear approximately 80 min after injection in PCC of representative MCI individual