Fig. 1.

The E.coli multi-omic space is represented in Figure a: different layers represent different omics. Genomic layer (blue rectangles) presents binary discretized omic values, the same for the other layers. Multi-omics in steady state conditions could be perturbed by induced treatmens thus increasing the number of layers for each multi-omic space. Then, the number of perturbed layers depends on the number of experiment considered. Recurring multi-omic patterns motifs related with pathways are represented with multi-omic layers structure (MLS), as shown in Figure b. Figure b part (1) represents the j-th pathway in relation with its associated set of genes (Figure b part (2)); the resultant multi-omic pattern is shown in Figure b part (3). The recurring multi-omic pattern is an array of pathway gene products multi-omic values arranged by the gene order. Multi-omics on the patterns are oscillating, in other words, low values follow high values and vice-versa. This feature is deeply related to the gene positions as shown in Figure c part (1) and (2). Oscillating multi-omics are present in succession along the pattern as shown in a₁ and a₂ of Figure d part (1). The patterns lose their oscillating features if two adjacent multi-omic values are not oscillating in an half (a₁ of Figure d part (2)) or completely (a₁ and a₂ of Figure d part (3))