Fig. 2.

In this Figure, the whole procedure block diagram is described. Gray blocks represent the extraction of multi-omic values and structures. Then, the global and the local effects (blue blocks) are computed. The local effect depends on the type of Multi-layered structure (network + sequence) (violet block). Once the multi-omic effects are computed and normalized, then these values are discretised in 0/1. After that, the oscillation measures are computed in the respective structures (networks and sequences). The generated multi-omic patterns (from sequences) and motifs (from networks) are given in input to the algorithm MORA for the computation of their reciprocal influences. This procedure is computed in standard conditions and after perturbations obtaining combined and competing patterns/motifs