Table 3.
Univariate and Multivariate Cox Regression Analysis for the Risk for Subsequent Multidrug-resistant Gram-negative Bacteria (MDRGNB) Infection after Hospital Discharge
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | p-value | HR | (95% CI) | p-value | |
| Age (per year increase) | 1.03 | (1.02–1.05) | < 0.001 | 1.02 | (1.01–1.03) | 0.007 |
| Male sex | 0.97 | (0.68–1.37) | 0.84 | – | – | – |
| LTCF residence | 2.59 | (1.43–4.70) | 0.002 | – | – | – |
| Long-term hemodialysis | 1.30 | (0.53–3.19) | 0.56 | – | – | – |
| Diabetes mellitus | 1.13 | (0.77–1.64) | 0.53 | – | – | – |
| Malignancy | 1.41 | (0.95–2.09) | 0.09 | 1.66 | (1.12–2.47) | 0.012 |
| End-stage renal disease | 0.96 | (0.39–2.34) | 0.93 | – | – | – |
| Liver cirrhosis | 0.65 | (0.32–1.33) | 0.24 | – | – | – |
| Congestive heart failure | 2.79 | (1.83–4.27) | < 0.001 | 1.70 | (1.08–2.68) | 0.021 |
| COPD | 2.73 | (1.80–4.15) | < 0.001 | 1.60 | (1.03–2.48) | 0.038 |
| Cerebrovascular accident | 1.75 | (1.17–2.64) | 0.007 | – | – | – |
| Presence of pressure sore | 2.32 | (1.31–4.12) | 0.004 | – | – | – |
| Central vascular cathetera,b | 1.83 | (1.01–3.32) | 0.046 | – | – | – |
| Long-term urinary catheterb | 1.72 | (1.00–3.00) | 0.05 | – | – | – |
| Antibiotics exposurec | 3.54 | (2.03–6.17) | < 0.001 | 2.20 | (1.25–3.90) | 0.007 |
| Intensive care unit admissionc | 1.26 | (0.59–2.70) | 0.55 | – | – | – |
| Receiving tracheal intubationc | 2.39 | (1.25–4.56) | 0.008 | – | – | – |
| MDRGNB culture positivec,d | 7.19 | (5.08–10.19) | < 0.001 | 5.35 | (3.72–7.71) | < 0.001 |
Abbreviations: LTCF long-term care facility, COPD chronic obstructive pulmonary disease
aIncludes Port-A catheter, Hickman catheter, permcath catheter, double-lumen catheter, and peripherally inserted central catheter
bAt the time of index hospitalization discharge
cDuring index hospitalization
dIncluding positive MDR-GNB culture from either surveillance or clinical culture of any anatomical site