Table 3.
Dental caries vaccine trials using human subjects
| Study | Immunization Route | Outcome Measure |
|---|---|---|
| Krasse et al.; 1978 | Topical | S. mutans specific IgA |
| Mestecky et al.; 1978 | Oral | S. mutans specific IgA |
| Gahnberg et al.; 1983 | Oral | S. mutans specific IgA; Recovery of S. mutans |
| Cole et al.; 1984 | Oral | Antibody response; Recovery of S. mutans |
| Gregory et al.; 1987 | Oral | S. mutans specific IgA; Recovery of S. mutans |
| Czerkinsky et al.; 1987 | Oral | S. mutans specific IgA or IgM |
| Smith et al.; 1987 | Oral | S. mutans specific IgA; S. mutans to total strep ratios |
| Ma et al.; 1987 | Passive | Recovery of S. mutans |
| Smith and Taubman; 1990 | Topical | Antibody against GTF; S. mutans to total strep ratios Recolonization with S. mutans |
| Ma et al.; 1990 | Passive | S. mutans colonization |
| Childers et al.; 1990 | Oral | Specific salivary IgA; Plasma IgG response |
| Filler et al.; 1991 | Passive | Recovery of S. mutans |
| Childers et al.; 1997 | Nasal | Specific salivary, nasal and serum IgA, IgM, and IgG |
| Hatta et al.; 1997 | Passive | S. mutans to total strep ratios |
| Ma et al.; 1998 | Passive | Protection against colonization |
| Childers et al.; 1999 | Nasal | Specific salivary, nasal and serum IgA and IgG |
| Shimazaki et al.; 2001 | Passive | Recolonization of S. mutans |
| Childers et al.; 2002 | Nasal | Specific salivary, nasal and serum IgA and IgG |