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. 2018 Jul 31;17:110. doi: 10.1186/s12943-018-0860-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CYTOR up-regulation in CRC samples with poor outcome. a Up-regulation of CYTOR in laser-microdissection-captured tumor budding cells, tumor cells compared with normal epithelial cells, n = 3 (CYTOR level represents the fluorescence signal value from microarray). b Higher expression of CYTOR in CRC samples than the matched normal tissues from our tissue bank, measured by qRT-PCR. c Kaplan-Meier plots of overall survival for CRC samples from our tissue bank, higher CYTOR expression with poorer survival. d Higher expression of CYTOR in CRC samples than the matched normal tissues from the TCGA database. e Kaplan-Meier plots of overall survival and f disease-free survival for CRC samples from the TCGA database, higher CYTOR expression with poorer survival. g Higher expression of CYTOR in CRC samples than the matched normal tissues from the GDS2947, h GSE31737, i GSE32323 and j GSE41328 databases. k Kaplan-Meier plots of overall survival and l recurrence-free survival for CRC samples from the GSE38832 database, higher CYTOR expression with poorer survival. m Kaplan-Meier plots of overall survival and n recurrence-free survival for CRC samples from the GSE39582 database, higher CYTOR expression with poorer survival