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. 2018 Jul 31;19:189. doi: 10.1186/s12882-018-0985-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — miRNA analysis of uEV from living and deceased donor. a Venn diagrams showing the shared and differential miRNA content in uEVs from LD (n = 5) and DD (n = 5) detected by next generation sequencing. 205 miRNAs overlap amongst the different samples analysed of LD and DD. Only the miRNAs shared within all donors of each group were taken for analysis. b Hierarchical clustering analysis of LD and DD uEV samples. Differential analysis of the miRNA content of uEVs from LD and DD. c Scatter plot analysis of miRNAs found in uEVs from LD and DD. Dot plot representing the -log of the p-value and the difference between the miRNA expression of LD and DD groups. Interestingly, only one miRNA was identified as statistically over-represented in LD (in bold, p < 0.05)