Table 3.
Clinical characteristics of kidney receptors
| Donor | uEV Analysis | Cold ischemia (hours) | Mismatch | Recipient’s previous KTx | DSA | IS | Delay Graft function | ACR | CHR | KB | Days until stable Renal function | SrCr (mg/dL) 1 year After KTx | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | DR | ||||||||||||
| LD1 | P, T | 2 | 0 | 0 | 0 | 1 | – | P, B, FK, MMf | – | – | – | – | 5 | 1 |
| LD2 | P, T | 2 | 1 | 1 | 1 | – | – | P, B, FK, MMf | – | – | – | – | 6 | 1.2 |
| LD3 | P, T | 2 | 1 | 1 | 2 | – | – | P, B, FK, MMf | – | – | – | – | 8 | 1.14 |
| LD4 | P, T | 2 | 1 | 1 | 1 | – | – | P, B, FK, MMf | Yes | Yes | – | ACR | – | – |
| LD5 | P, T | 4 | 1 | 2 | 1 | – | – | P, B, FK, MMf | ||||||
| DD1 | P, T | 20 | 2 | 2 | 1 | – | – | P, FK, MMf | – | – | – | – | 14 | 1,82 |
| Not transplanted | ||||||||||||||
| DD2 | P,T | 18 | 2 | 2 | 1 | – | – | P, B, FK, MMf | – | – | – | – | 20 | 1.77 |
| 22 | 0 | 0 | 1 | – | – | P, B, FK, MMf | – | – | – | – | 15 | 1.23 | ||
| DD3 | P,T | 18 | 1 | 1 | 1 | – | – | P, FK, Th, Everolimus | – | – | – | – | 7 | 1.45 |
| Not transplanted | ||||||||||||||
| DD4 | T | 20 | 1 | 1 | 1 | – | – | P, B, FK, MMf | – | – | – | CNTI | 15 | 1.67 |
| 15 | 1 | 2 | 1 | – | – | P, B, FK, MMf | – | – | – | ATN, TAIF | 6 | 2.6 | ||
| DD5 | T | 20 | 1 | 2 | 2 | – | – | P, B, FK, MMf | – | – | – | – | 9 | 1.64 |
| 17 | 1 | 1 | 1 | – | – | Eculizumab, P, FK, MMF, Th | – | – | – | – | 24 | 1.39 | ||
| DD6 | P | 13 | 2 | 2 | 1 | – | – | P, B, FK, MMf | – | Yes | – | ACR | 24 | 1.03 |
| 22 | 1 | 1 | 1 | – | Yes | P,FK; MMf, Th | – | – | – | – | 25 | 1.16 | ||
| DD7 | P | 17 | 2 | 2 | 1 | – | – | P, B, FK, MMf | Yes | – | – | – | 30 | 1.01 |
| 20 | 1 | 1 | 1 | – | – | P, B, FK, MMf | – | – | – | – | 30 | 1.01 | ||
A summary of the HLA-mismatch, donor specific antibodies (DSA), cold ischemia time, previous transplants, immunosuppression treatment, delay graft function and renal biopsy are provided. P: sample used for proteomic assays. T: sample used for transcriptomic NGS assays
KTx Kidney transplantation, DSA donor specific antibodies, IS immunosuppression treatment, ACR acute cellular rejection, CHR chronic humoral rejection, KB kidney biopsy, P Prednisone, FK Tacrolimus, MMf mycophenolate mofetil, B Basiliximab, Th Thymoglobulin, ATN Acute tubular necrosis, CNIT calcineurin inhibitor toxicity, TAIF tubular atrophy and interstitial fibrosis, AS arteriosclerosis