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. 2018 Jul 31;10:100. doi: 10.1186/s13148-018-0531-y

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cellular effects of 19i treatment in urothelial carcinoma cell lines. a Caspase 3/7 activity (24 and 48 h) and b cleaved PARP (48 h) were monitored in UCCs VM-CUB1, UM-UC-3, and 639-V after treatment with 19i (2 μM) or SAHA (2.5 μM). c Quantitative analysis of nuclear morphology, based on DAPI stainings, in UCCs VMCUB1 and UM-UC-3. The percentages of mitoses and micronuclei are shown after treatment with HDACi 19i (2 μM), SAHA (2.5 μM), or DMSO for 24 or 48 h. The calculated significances refer to the DMSO solvent control (*p < 0.05). Data in a and c are mean from n = 3; the blot in b shows a representative experiment