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. 2018 Jul 31;10:100. doi: 10.1186/s13148-018-0531-y

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effects of 19i treatment on gene expression and acetylation status in HDAC4-overexpressing UCCs. Gene expression and protein acetylation in VM-CUB1 and UM-UC-3 cell lines lentivirally transduced to overexpress HDAC4 compared to the parental cells and cell lines transduced with empty vector (LV). a Expression of HDAC4, HDAC5, HDAC7, and HDAC9 mRNAs. The calculated significances refer to the respective parental cell line (*p < 0.05). b TS and p21^CIP1 mRNA expression following treatment with 19i (2 μM) or SAHA (2.5 μM) for 48 h. The calculated significances refer to the DMSO solvent control (*p < 0.05). Acetylation of α-tubulin and histones H3 or H4 after 19i treatment (1 and 2 μM) after 48 h. Data in a and b are mean from n = 3; the blot in c shows a representative experiment