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. 2018 Jul 31;18:772. doi: 10.1186/s12885-018-4690-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Silencing of BMX, NRTK2, and PDPK1 upregulated in LRCC increases response to gemcitabine in pancreas cancer cells. a anti-BMX, NRTK2 and PDPK1 siRNA leads to increased sensitivity to gemcitabine compared to cells with intact BMX, NRTK2 and PDPK1. Full drug response curves in MiaPaCa2, Panc-1, and Nor-P1 cells including cells transfected with scramble siRNA and indicated target siRNAs are shown. Gemcitabine concentration in logM on x-axis. b Induction of apoptosis in MiaPaCa2, Panc-1, and Nor-P1 cells treated with gemcitabine upon silencing of BMX, NRTK2, or PDPK1 (compared to scramble siRNA cells)