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. 2018 Feb 21;14(5):845–861. doi: 10.1080/15548627.2017.1390636

Figure 2.

Figure 2.

PLG restores TH expression in a mouse model of rotenone-induced PD. C57BL mice were treated with rotenone (10 mg/kg) for 6 wk followed by PLG (2 or 4 mg/kg) or l-dopa (20 mg/kg) for 4 wk. (A) TH (tyrosine hydroxylase) expression in the midbrain and striatum was assessed by immunohistochemistry. Scale bar: 500 μm. (B, C) Quantitative analysis of TH-positive neurons in the striatum (B) and midbrain (C). (D) TH expression in the midbrain and striatum was determined by western blotting. (E, F) Quantitative analysis of TH expression in the striatum (E) and midbrain (F). (G) Dopamine (DA) content in the striatum was assessed by HPLC. (H) Activity of mitochondrial complex I in the midbrain. Data are expressed as the mean ± SD (one-way analysis of variance). ###P<0.001 vs. control (Con); **P<0.01 vs. rotenone (Rot) (n = 5).