Table 1.
Comparison |
Mean difference | 95% CI | Adjusted P value | |
---|---|---|---|---|
group A | group B | |||
1 day post-infection | ||||
rezafungin 20 mg/kg ip | micafungin 5 mg/kg ip | −0.20 | −0.99 to 0.59 | 0.8801 |
rezafungin 20 mg/kg ip | amphotericin B 0.3 mg/kg ip | −0.85 | −1.59 to −0.10 | 0.0231b |
rezafungin 20 mg/kg ip | vehicle ip | −1.04 | −1.79 to −0.30 | 0.0052b |
4 days post-infection | ||||
rezafungin 20 mg/kg ip | micafungin 5 mg/kg ip | −0.72 | −1.75 to 0.32 | 0.2339 |
rezafungin 20 mg/kg ip | amphotericin B 0.3 mg/kg ip | −3.30 | −4.34 to −2.27 | <0.0001b |
rezafungin 20 mg/kg ip | vehicle ip | −3.21 | −4.24 to −2.17 | <0.0001b |
7 days post-infection | ||||
rezafungin 20 mg/kg ip | micafungin 5 mg/kg ip | −0.78 | −1.83 to 0.27 | 0.1836 |
rezafungin 20 mg/kg ip | amphotericin B 0.3 mg/kg ip | −3.99 | −5.04 to −2.94 | <0.0001b |
rezafungin 20 mg/kg ip | vehicle ip | −3.85 | −4.90 to −2.80 | <0.0001b |
10 days post-infection | ||||
rezafungin 20 mg/kg ip | micafungin 5 mg/kg ip | −1.34 | −2.41 to −0.26 | 0.0128b |
rezafungin 20 mg/kg ip | amphotericin B 0.3 mg/kg ip | −3.69 | −4.76 to −2.61 | <0.0001b |
rezafungin 20 mg/kg ip | vehicle ip | −2.89 | −3.96 to −1.81 | <0.0001b |
ip, intraperitoneally.
Tukey’s multiple comparisons test.
Statistically significant results.