FIGURE 2.

BDL is associated with functional renal failure in rats. A 24-h urine sample was collected from animals placed in metabolic cages followed by blood collection. Urinary and serum creatinine were measured and CrCl was calculated. (A) CrCl at various time points, (B) BUN and (C) renal perfusion pressure were measured in rats 5 weeks after sham or BDL surgery, as described in the ‘Materials and Methods’ section. Values are represented as the mean ± SEM; n = 8 per group. *P < 0.05, **P < 0.001 versus sham group.