Figure 2.

The effect of the fatty acid amide hydrolase inhibitor, PF-3845 (5 mg/kg, i.p. injection), on hippocampal (A) inducible nitric oxide synthase (Nos2) and (B) neuronal nitric oxide synthase (Nos1) mRNA expression from control and stressed rats (n=5–6/group). The relative expression was determined in the dorsal hippocampus collected from rats exposed to 0 (control), 60, 240, and 360 minutes of acute restraint stress. Data are presented as mean±SEM ^†P<.05 and ^†††P<.001 vs vehicle-treated group at 0 (control) minute; *P<.05 between vehicle- and PF-3845-treated groups at each respective time-point.