Table 1.

Memorial Sloan Kettering Cancer Center Grading Criteria for Cytokine Release Syndrome

Grade	Definitions
1	Mild symptoms, requiring observation or symptomatic management only (eg, antipyretics, antiemetics, pain medications)
2	Moderate symptoms: hypotension requiring vasopressors for <24 h or hypoxia or dyspnea requiring supplemental oxygen <40% (up to 6 L by nasal cannula)
3	Severe symptoms: hypotension requiring vasopressors for ≥24 h or hypoxia or dyspnea requiring supplemental oxygen ≥40%
4	Life-threatening symptoms: hypotension refractory to vasopressors or hypoxia or dyspnea requiring mechanical ventilation
5	Death