Table 4.
Univariate and Multivariate Cox Models for Predictors of Infection and Bloodstream Infection
| Variable | Predictors of Infection | Predictors of Bloodstream Infection | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate HR (95% CI) | P Value | Multivariate HR (95% CI) | P Value | Univariate HR (95% CI) | P Value | Multivariate HR (95% CI) | P Value | |
| Age ≥50 y | 1.04 (.43–2.39) | .92 | … | … | 0.64 (.12–2.51) | .54 | … | … |
| Female sex | 1.29 (.51–3.00) | .57 | … | … | 2.76 (.71–10.69) | .14 | 2.63 (.67–10.37) | .16 |
| Prior chemotherapy (≥3 lines) | 0.86 (.38–2.03) | .72 | … | … | 1.66 (.42–9.04) | .48 | … | … |
| Prior allogeneic HSCT | 0.77 (.30–1.79) | .55 | … | … | 1.07 (.25–4.03) | .92 | … | … |
| Conditioning regimen | ||||||||
| Cy 1.5 g/m2 | 1.00 (—) | … | 1.00 (—) | … | 1.00 (—) | … | … | … |
| Cy 3.0 g/m2 | 0.47 (.18–1.36) | .16 | 0.35 (.12–1.05) | .06 | 1.12 (.21–11.16) | .9 | … | … |
| Cy/Flu or Cy/Clo | 1.41 (.49–4.21) | .52 | 0.83 (.23–3.02) | .77 | 2.58 (.42–26.63) | .31 | … | … |
| Morphologic disease (≥5% blasts or extramedullary disease) | 1.76 (.74–4.72) | .21 | 0.65 (.18–2.25) | .50 | 1.72 (.44–9.35) | .45 | … | … |
| CAR T-cell dose (3 × 106/kg vs 1 × 106/kg) | 0.44 (.19–1.01) | .05 | 0.47 (.16–1.35) | .16 | 0.72 (.19–2.78) | .62 | … | … |
| Hypogammaglobulinemia (IgG <600 mg/dL) | 1.10 (.32–5.66) | .89 | … | … | 2.21 (.24–292.76) | .56 | … | … |
| CRS grade ≥3a | 2.64 (1.11–6.03) | .03 | 2.67 (1.00–7.34) | .05 | 20.21 (4.40–192.13) | <.001 | 19.97 (4.32–190.31) | <.001 |
Abbreviations: CAR, chimeric antigen receptor; CI, confidence interval; Clo, clofarabine; CRS, cytokine release syndrome; Cy, cyclophosphamide; Flu, fludarabine; HR, hazard ratio; HSCT, hematopoietic stem cell transplantation; IgG, immunoglobulin G.
aAnalyzed as a time-dependent predictor. All the analysis time was CRS grade 3–4.