FIG. 5.

Temporal progression of global neuropathology in the brains of rats acutely intoxicated with diisopropylfluorophosphate (DFP). A, Temporal progression curves of DFP-induced neuropathology, as modeled using scores for global neuronal necrosis and neuroinflammatory responses. Each individual symbol represents data from a single animal. Vertical dashed lines identify boundaries between stages of neuropathology as defined in Figure 3. Each curve is modeled on data from the 39 animals that reached a maximal seizure score of ≥ 3, which is consistent with the induction of status epilepticus. B, Box plots indicating estimated global peak severity (vertical black bar) and 95% confidence interval (box) of data in (A). NN, neuronal necrosis; IBA1, microgliosis; GFAP, reactive astrogliosis.