Table 3. Patient characteristic subgroup means and correlations with PRO measures.
| PATIENT CHARACTERISTICS | Number of Comorbid Conditions | TMSAS | Depression | Anger | Anxiety | Cognitive Concerns | Pain Interference | Fatigue | Sleep Disturbance | Belly Pain | Diarrhea | Nausea/ Vomiting | HCV-PRO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | Mean | |
| r | r | r | r | r | r | r | r | r | r | r | r | r | |
| SOCIODEMOGRAPHICS | |||||||||||||
| Age (Mean = 57 years old) | 0.23 | -0.05 | -0.13 | -0.19 | -0.16 | -0.13 | 0.00 | -0.13 | -0.09 | -0.09 | 0.03 | -0.10 | 0.12 |
| Sex | 0.07 | 0.15 | 0.10 | 0.06 | 0.06 | 0.08 | 0.04 | 0.15 | 0.05 | 0.08 | 0.05 | 0.06 | 0.05 |
| Male | 3.8 | 0.5 | 48.4 | 48.3 | 49.8 | 32.3 | 52.6 | 50.3 | 51.2 | 35.1 | 35.2 | 41.2 | 72.6 |
| Female | 4.2 | 0.7 | 50.5 | 49.7 | 51.1 | 33.8 | 53.5 | 53.6 | 52.5 | 37.3 | 36.1 | 42.2 | 70.5 |
| Race | 0.06 | 0.12 | 0.13 | 0.15 | 0.13 | 0.13 | 0.04 | 0.18 | 0.13 | 0.10 | 0.03 | 0.11 | 0.14 |
| Black | 4.1 | 0.5 | 47.4 | 46.4 | 48.6 | 31.2 | 52.3 | 49.0 | 49.7 | 34.3 | 35.3 | 40.5 | 76.0 |
| White | 3.9 | 0.6 | 50.2 | 50.1 | 51.1 | 33.8 | 53.2 | 53.0 | 52.7 | 36.8 | 35.7 | 42.0 | 69.9 |
| Other | 4.5 | 0.7 | 51.3 | 50.6 | 53.1 | 33.8 | 53.7 | 53.9 | 53.2 | 38.5 | 36.3 | 43.8 | 66.8 |
| Marital Status | 0.11 | 0.13 | 0.13 | 0.03 | 0.12 | 0.07 | 0.14 | 0.10 | 0.07 | 0.10 | 0.03 | 0.10 | 0.13 |
| Single | 4.0 | 0.6 | 49.5 | 48.7 | 50.6 | 33.1 | 53.0 | 51.0 | 51.6 | 36.1 | 35.6 | 41.6 | 71.2 |
| Divorced, Separated, Widowed | 4.5 | 0.7 | 51.1 | 49.4 | 52.0 | 33.8 | 55.1 | 53.5 | 53.0 | 38.0 | 36.0 | 42.9 | 67.8 |
| Married, domestic partner | 3.6 | 0.5 | 47.8 | 48.6 | 48.9 | 32.3 | 51.3 | 51.2 | 51.0 | 34.7 | 35.3 | 40.7 | 75.0 |
| Education | 0.10 | 0.11 | 0.08 | 0.08 | 0.08 | 0.08 | 0.11 | 0.01 | 0.09 | 0.08 | 0.05 | 0.11 | 0.08 |
| ≤ High school diploma | 4.3 | 0.6 | 50.0 | 49.6 | 51.1 | 33.7 | 54.0 | 51.9 | 52.7 | 37.1 | 36.0 | 42.5 | 70.1 |
| > High school diploma | 3.7 | 0.5 | 48.4 | 47.9 | 49.5 | 32.2 | 51.7 | 51.6 | 50.6 | 34.9 | 35.1 | 40.7 | 73.6 |
| Annual Income | 0.20 | 0.20 | 0.18 | 0.09 | 0.15 | 0.13 | 0.25 | 0.13 | 0.13 | 0.16 | 0.07 | 0.15 | 0.22 |
| ≤ $40K | 4.3 | 0.6 | 50.4 | 49.4 | 51.3 | 33.7 | 54.6 | 52.6 | 52.6 | 37.3 | 35.9 | 42.4 | 68.8 |
| > $41K | 3.0 | 0.4 | 46.1 | 47.2 | 47.7 | 30.9 | 48.2 | 49.3 | 49.1 | 32.5 | 34.5 | 39.5 | 80.3 |
| Employment | 0.40 | 0.36 | 0.28 | 0.19 | 0.27 | 0.27 | 0.42 | 0.24 | 0.26 | 0.27 | 0.17 | 0.26 | 0.39 |
| Working full or part time | 2.7 | 0.4 | 46.0 | 47.1 | 47.7 | 30.5 | 48.1 | 49.2 | 48.7 | 32.3 | 33.8 | 39.3 | 80.4 |
| Receiving or applying for disability | 5.2 | 0.8 | 52.2 | 51.0 | 53.1 | 35.5 | 57.9 | 54.3 | 54.7 | 39.6 | 37.0 | 44.0 | 62.6 |
| Unemployed | 3.3 | 0.6 | 51.6 | 50.0 | 52.7 | 33.9 | 52.8 | 53.4 | 53.7 | 38.3 | 36.4 | 42.1 | 69.0 |
| Retired/homemaker/student | 3.7 | 0.4 | 46.7 | 45.8 | 46.8 | 30.2 | 49.0 | 48.6 | 48.5 | 33.3 | 34.8 | 39.7 | 81.0 |
| Health insurance | 0.32 | 0.24 | 0.19 | 0.13 | 0.18 | 0.17 | 0.31 | 0.17 | 0.20 | 0.20 | 0.11 | 0.22 | 0.27 |
| Private insurance | 2.8 | 0.4 | 46.7 | 47.1 | 48.0 | 31.0 | 48.5 | 49.4 | 48.9 | 32.8 | 34.3 | 39.3 | 79.6 |
| Public insurance Medicaid/Medicare | 4.9 | 0.7 | 50.5 | 49.5 | 51.5 | 34.2 | 55.7 | 53.3 | 53.3 | 38.2 | 36.3 | 43.0 | 66.7 |
| Uninsured or hospital assistance | 3.9 | 0.6 | 51.7 | 51.5 | 53.0 | 34.3 | 54.8 | 52.7 | 53.8 | 38.0 | 36.2 | 43.4 | 68.1 |
| LIVER LAB & CLINICAL MARKERS | |||||||||||||
| HCV RNA viral load (log10IU/ml) (Mean = 6) | 0.03 | 0.04 | 0.04 | 0.02 | 0.02 | 0.03 | 0.05 | 0.03 | 0.01 | 0.02 | 0.04 | 0.01 | -0.04 |
| AST (IU/L) (Mean = 70) | 0.00 | 0.06 | 0.03 | 0.04 | -0.02 | 0.02 | -0.01 | 0.03 | 0.08 | 0.04 | 0.03 | 0.01 | -0.05 |
| ALT (IU/L) (Mean = 78) | -0.07 | 0.00 | 0.02 | 0.08 | 0.00 | 0.01 | -0.04 | 0.02 | 0.06 | -0.01 | -0.03 | -0.03 | -0.05 |
| Albumin (g/dL) (Mean = 4) | -0.18 | -0.16 | -0.05 | -0.02 | -0.01 | -0.03 | -0.11 | -0.09 | -0.08 | -0.12 | -0.14 | -0.08 | 0.09 |
| Total Bilirubin (mg/dL (Mean = 1) | 0.01 | 0.04 | -0.01 | -0.03 | -0.03 | -0.02 | -0.02 | -0.01 | 0.05 | 0.01 | 0.02 | 0.03 | -0.01 |
| Platelets (103/μL) (Mean = 197) | -0.05 | -0.06 | -0.04 | -0.06 | 0.00 | -0.03 | 0.01 | -0.02 | -0.05 | -0.04 | -0.07 | 0.00 | 0.06 |
| Hemoglobin (g/dL) (Mean = 14) | -0.18 | -0.12 | 0.00 | 0.01 | 0.02 | -0.01 | -0.07 | -0.07 | -0.01 | -0.07 | -0.11 | -0.06 | 0.00 |
| Creatinine (mg/dL) (Mean = 1) | 0.13 | 0.02 | 0.00 | 0.00 | -0.02 | -0.02 | 0.05 | 0.02 | 0.03 | 0.00 | 0.04 | 0.06 | -0.01 |
| INR (Mean = 1) | 0.10 | 0.07 | 0.02 | 0.02 | 0.01 | 0.03 | 0.04 | 0.04 | 0.06 | 0.10 | 0.11 | 0.06 | -0.06 |
| Cirrhosis status | 0.07 | 0.05 | 0.03 | 0.01 | 0.02 | 0.05 | 0.02 | 0.03 | 0.05 | 0.05 | 0.03 | 0.02 | 0.05 |
| No | 3.8 | 0.5 | 48.9 | 49.0 | 50.6 | 32.7 | 52.7 | 51.4 | 51.3 | 35.4 | 35.3 | 41.5 | 72.8 |
| Yes | 4.2 | 0.6 | 49.7 | 48.7 | 50.2 | 33.3 | 53.2 | 52.1 | 52.3 | 36.7 | 35.9 | 41.9 | 70.6 |
| If cirrhotic, MELD score | 0.09 | 0.09 | 0.05 | 0.00 | 0.02 | 0.05 | 0.04 | 0.05 | 0.06 | 0.06 | 0.05 | 0.06 | 0.07 |
| MELD 6–11 | 4.0 | 0.6 | 49.4 | 48.3 | 49.8 | 33.1 | 53.3 | 51.9 | 51.9 | 36.3 | 35.1 | 41.5 | 71.4 |
| MELD ≥ 12 | 5.3 | 0.8 | 51.4 | 50.8 | 51.9 | 34.8 | 55.1 | 54.9 | 55.2 | 40.1 | 40.2 | 44.9 | 64.5 |
| AST to Platelet Ratio Index (APRI) | 0.02 | 0.09 | 0.07 | 0.06 | 0.01 | 0.06 | 0.00 | 0.08 | 0.10 | 0.07 | 0.11 | 0.05 | 0.09 |
| APRI ≤ 2.0 | 4.0 | 0.6 | 49.0 | 38.6 | 50.3 | 32.7 | 53.0 | 51.4 | 51.3 | 35.7 | 35.2 | 41.5 | 72.6 |
| APRI > 2.0 | 4.2 | 0.7 | 51.0 | 50.6 | 50.8 | 34.4 | 53.1 | 54.1 | 54.8 | 38.3 | 38.0 | 42.8 | 66.5 |
| Fibrosis-4 | 0.06 | 0.07 | 0.02 | 0.00 | 0.02 | 0.01 | 0.01 | 0.02 | 0.03 | 0.04 | 0.07 | 0.03 | 0.03 |
| FIB-4 ≤ 3.25 | 3.9 | 0.5 | 49.1 | 48.9 | 50.5 | 32.9 | 52.9 | 51.6 | 51.6 | 35.7 | 35.2 | 41.5 | 72.2 |
| FIB-4 > 3.25 | 4.3 | 0.6 | 49.7 | 48.8 | 50.1 | 33.1 | 53.3 | 52.2 | 52.4 | 36.9 | 36.5 | 42.1 | 70.7 |
| PSYCHIATRIC AND SUBSTANCE USE MARKERS | |||||||||||||
| History of psychiatric medication use | 0.21 | 0.35 | 0.38 | 0.30 | 0.36 | 0.33 | 0.27 | 0.30 | 0.24 | 0.20 | 0.10 | 0.19 | 0.38 |
| No | 3.4 | 0.4 | 45.3 | 45.5 | 46.7 | 30.0 | 50.0 | 48.5 | 49.0 | 33.5 | 34.7 | 40.0 | 80.0 |
| Yes | 4.6 | 0.7 | 53.2 | 52.2 | 54.0 | 36.0 | 55.9 | 55.0 | 54.5 | 38.6 | 36.4 | 43.2 | 63.2 |
| Currently on psychiatric medications | 0.12 | 0.23 | 0.22 | 0.12 | 0.19 | 0.19 | 0.14 | 0.16 | 0.04 | 0.15 | 0.10 | 0.13 | 0.17 |
| No | 4.2 | 0.6 | 50.3 | 50.5 | 51.5 | 33.8 | 53.9 | 53.0 | 53.9 | 36.0 | 35.2 | 41.8 | 67.9 |
| Yes | 4.9 | 0.8 | 55.1 | 53.3 | 55.6 | 37.4 | 57.1 | 56.3 | 54.8 | 40.3 | 37.1 | 44.2 | 60.0 |
| History of mental health diagnosis | 0.24 | 0.33 | 0.36 | 0.28 | 0.35 | 0.33 | 0.27 | 0.29 | 0.20 | 0.17 | 0.11 | 0.20 | 0.37 |
| No | 3.4 | 0.4 | 46.0 | 46.0 | 47.3 | 30.3 | 50.3 | 49.0 | 49.7 | 34.1 | 34.7 | 40.1 | 79.0 |
| Yes | 4.8 | 0.8 | 53.6 | 52.5 | 54.4 | 36.4 | 56.3 | 55.3 | 54.3 | 38.6 | 36.7 | 43.6 | 62.1 |
| History of mental health treatment or services | 0.16 | 0.27 | 0.30 | 0.25 | 0.30 | 0.29 | 0.17 | 0.24 | 0.15 | 0.14 | 0.09 | 0.18 | 0.29 |
| No | 3.6 | 0.5 | 46.7 | 46.6 | 47.8 | 30.8 | 51.4 | 49.5 | 50.3 | 34.6 | 34.9 | 40.3 | 77.2 |
| Yes | 4.5 | 0.7 | 53.0 | 52.2 | 54.0 | 36.1 | 55.1 | 54.9 | 53.7 | 38.2 | 36.5 | 43.4 | 64.0 |
| History of psychiatric hospitalization | 0.15 | 0.24 | 0.24 | 0.21 | 0.26 | 0.25 | 0.14 | 0.19 | 0.11 | 0.15 | 0.10 | 0.18 | 0.24 |
| No | 3.8 | 0.5 | 48.1 | 47.8 | 49.2 | 31.9 | 52.2 | 50.8 | 51.1 | 35.2 | 35.2 | 40.9 | 74.2 |
| Yes | 4.9 | 0.8 | 54.7 | 53.9 | 55.9 | 37.9 | 56.4 | 56.2 | 54.5 | 40.1 | 37.5 | 44.8 | 60.0 |
| Frequency of current alcohol consumption | 0.08 | 0.10 | 0.03 | 0.03 | 0.09 | 0.09 | 0.09 | 0.06 | 0.05 | 0.11 | 0.02 | 0.04 | 0.09 |
| Never | 4.2 | 0.6 | 49.6 | 49.2 | 51.1 | 33.6 | 53.7 | 52.3 | 52.2 | 37.1 | 35.7 | 41.9 | 70.2 |
| Weekly to monthly consumption | 3.7 | 0.5 | 48.9 | 48.4 | 49.2 | 31.8 | 51.6 | 50.9 | 51.1 | 34.3 | 35.4 | 41.2 | 74.4 |
| Number of alcoholic drinks on a drinking day | 0.09 | 0.10 | 0.03 | 0.03 | 0.09 | 0.09 | 0.10 | 0.06 | 0.05 | 0.12 | 0.02 | 0.04 | 0.09 |
| None | 4.2 | 0.6 | 49.6 | 49.2 | 51.1 | 33.6 | 53.8 | 52.2 | 52.3 | 37.3 | 35.7 | 41.9 | 70.1 |
| 1+ | 3.7 | 0.5 | 48.9 | 48.5 | 49.3 | 31.9 | 51.6 | 51.0 | 51.0 | 34.1 | 35.3 | 41.2 | 74.2 |
| Use of nonprescription street drugs in last year | 0.00 | 0.07 | 0.10 | 0.11 | 0.08 | 0.07 | 0.02 | 0.03 | 0.07 | 0.04 | 0.03 | 0.09 | 0.05 |
| Never | 4.0 | 0.6 | 48.8 | 48.3 | 50.0 | 32.7 | 52.8 | 51.6 | 51.4 | 35.8 | 35.4 | 41.2 | 72.2 |
| Daily to monthly | 4.0 | 0.6 | 51.3 | 51.3 | 52.1 | 34.2 | 53.5 | 52.4 | 53.5 | 37.0 | 36.2 | 43.3 | 69.3. |
| Use of prescription drugs to get high or change the way you feel in last year | 0.05 | 0.12 | 0.14 | 0.15 | 0.13 | 0.14 | 0.07 | 0.11 | 0.11 | 0.08 | 0.07 | 0.15 | 0.12 |
| Never | 4.0 | 0.6 | 48.8 | 48.3 | 50.0 | 32.6 | 52.7 | 51.4 | 51.4 | 35.8 | 35.4 | 41.2 | 72.5 |
| Daily to monthly | 4.5 | 0.8 | 54.2 | 54.4 | 54.5 | 36.9 | 55.6 | 55.7 | 55.8 | 39.2 | 37.4 | 45.8 | 63.1 |
Mean scores for all patient characteristic subgroups by PRO measures and correlation coefficients (r) as degree of relationship between the predictor variable and PRO measure. Correlations range from 0 (no association) to +/- 1.0 (perfect association).