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. 2018 Aug 1;13(8):e0196908. doi: 10.1371/journal.pone.0196908

Table 6. MSAS symptoms reported by at least 25% of patients.

Symptoms % Endorsed % Severitya % Frequencyb % Distressingc
Lack of energy 60 50 39 43
Pain 52 46 37 42
Difficulty sleeping 48 42 34 35
Worrying 43 33 23 28
Numbness/tingling in hands/feet 40 31 23 26
Feeling drowsy 37 28 17 21
Dry mouth 34 24 18 17
Feeling irritable 32 22 12 20
Difficulty concentrating 31 20 13 20
Feeling nervous 31 24 14 21
Feeling sad 29 22 13 20
Cough 27 17 12 12
Feeling bloated 27 20 13 17
Shortness of breath 25 19 11 17
Itching 25 18 11 15

Symptom severity, frequency and distress are reported as percentages of those who endorsed the symptom presence.

a Severity ranges from slight, moderate, severe, very severe; data shown is % reporting moderate, severe, very severe symptoms.

b Frequency ranges from rarely, occasionally, frequently, almost constantly; data shown is % reported frequently or almost constantly.

c Distress or bothersome ranges from not at all, a little bit, somewhat, quite a bit, very much; data shown is % reporting symptoms as somewhat, quite a bit, or very much distressing.