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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurobiol Dis. 2017 Oct 7;109(Pt A):76–87. doi: 10.1016/j.nbd.2017.10.004

Figure 5.

Figure 5

miR-32-5p targets and inhibits SLC12A5 at the transcript level. Computational analysis revealed that the highest scoring microRNA predicted to target the SLC12A5 3’ UTR was miR-32-5p. A) Gene and microRNA expression profiles measured with qPCR demonstrate a significant anti-correlation between miR-32-5p and SLC12A5 expression in our set of TSC tubers (P≤ 0.0001). B) A luciferase reporter assay was used to confirm that miR-32 directly targets the 3’ UTR of SLC12A5 and causes transcript repression.