Table 4. Target genes in the enriched functional categories of synapse (S), ion transport (I), and epilepsy (E).
Each gene was predicted as a high confidence target by computational analysis and also had a significant anti-correlation of expression compared to the targeting microRNA.
| UNIGENE | Gene Symbol | Description | Category |
|---|---|---|---|
| Hs.483239 | ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | E |
| Hs.4993 | PCDH19 | protocadherin 19 | E |
| Hs.649965* | MEF2C | myocyte enhancer factor 2C | E |
| Hs.655684 | CNTNAP2 | contactin associated protein-like 2 | E |
| Hs.370854 | TSC1 | tuberous sclerosis 1 | E |
| Hs.553187 | KCNH1 | potassium channel, voltage gated eag related subfamily H, member 1 | E, I |
| Hs.21413* | SLC12A5 | solute carrier family 12 member 5 | E, I |
| Hs.436550* | SCN8A | sodium voltage-gated channel alpha subunit 8 | E, I |
| Hs.506759 | ATP2A2 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | E, I |
| Hs.93485* | SCN2A | sodium voltage-gated channel alpha subunit 2 | E, I |
| Hs.411472* | GRIN2A | glutamate ionotropic receptor NMDA type subunit 2A | E, I, S |
| Hs.654430* | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | E, I, S |
| Hs.84244* | KCNB1 | potassium voltage-gated channel subfamily B member 1 | E, I, S |
| Hs.118262 | CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | I |
| Hs.658489 | CLCC1 | chloride channel CLIC-like 1 | I |
| Hs.134190 | NIPAL1 | NIPA-like domain containing 1 | I |
| Hs.148907 | SLC5A12 | solute carrier family 5 member 12 | I |
| Hs.153521 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | I |
| Hs.250083 | SLC9A2 | solute carrier family 9 member A2 | I |
| Hs.274579 | CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | I |
| Hs.47288 | TRPM3 | transient receptor potential cation channel subfamily M member 3 | I |
| Hs.506276 | ATP2B1 | ATPase plasma membrane Ca2+ transporting 1 | I |
| Hs.514870 | ATP5F1 | ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 | I |
| Hs.411299 | KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | I |
| Hs.658533 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | I |
| Hs.482017 | LRRC8B | leucine rich repeat containing 8 family, member B | I |
| Hs.5462 | SLC4A4 | solute carrier family 4 member 4 | I |
| Hs.4749 | SLC4A8 | solute carrier family 4, sodium bicarbonate cotransporter, member 8 | I |
| Hs.91389 | SLC9A7 | solute carrier family 9 member A7 | I |
| Hs.516866 | SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | I |
| Hs.385530 | SLC24A4 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 | I |
| Hs.116250 | GABRA2 | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | I, S |
| Hs.2700 | GLRA2 | glycine receptor alpha 2 | I, S |
| Hs.631595 | CACNG8 | calcium voltage-gated channel auxiliary subunit gamma 8 | I, S |
| Hs.661870 | KCTD16 | potassium channel tetramerization domain containing 16 | I, S |
| Hs.440379 | ARHGAP32 | Rho GTPase activating protein 32 | S |
| Hs.370510 | CADM1 | cell adhesion molecule 1 | S |
| Hs.164578 | CADM2 | cell adhesion molecule 2 | S |
| Hs.535891 | CHRM2 | cholinergic receptor, muscarinic 2 | S |
| Hs.367656 | DLG2 | discs large MAGUK scaffold protein 2 | S |
| Hs.159291 | DRP2 | dystrophin related protein 2 | S |
| Hs.103183 | FMR1 | fragile X mental retardation 1 | S |
| Hs.478289 | NLGN1 | neuroligin 1 | S |
| Hs.655271 | RIMS2 | regulating synaptic membrane exocytosis 2 | S |
| Hs.21754 | SV2B | synaptic vesicle glycoprotein 2B | S |
| Hs.310545* | SYT1 | synaptotagmin 1 | S |
| Hs.32984 | SYT11 | synaptotagmin 11 | S |
| Hs.569438 | TLN2 | talin 2 | S |
*
Bold text: Validated with qPCR
I: Ion transport
S: Synapse
E: Epilepsy