Figure 1. Natural compound screening procedure: A total of 240 in -house natural plant-derived chemicals (<65 μg/ml) and 1,400 botanical herbs (<200 μg/ml) were tested for capacity to induce cytotoxicity on MDA-MB-231 cells, relative to chemotherapy drugs. Lead compounds Frankincense (Boswellia serrata extract (BSE)) and 3-O-Acetyl-β-boswellic acid (3-OAβBA) were then cultured for 8 hours at the LC₅₀, prior to cell death – and immediately frozen at –80˚C. Microarray analysis was performed to identify biological influence on the entire transcriptome.