Table 2.

Changes in Variables after 12 Months of Vitamin D Supplementation

A. Absolute Changes over 12 Months
Median (quartile 1, quartile 3)	All Subjects (N=51)	P∘	Standard Dose† (N=21)	P∘	Moderate Dose‡ (N=18)	P∘	High Dose¥ (N=12)	P∘	P*
25(OH)D, ng/mL	+15.6 (+9.2, +30.1)	<0.0001	+14.7 (+12.0, +18.1)	<0.0001	+19.2 (+10.0, +32.0)	<0.0001	+31.0 (+16.2, +41.1)	<0.0001	0.001
Body mass index, kg/m2	+0.67 (−0.49, +1.38)	0.02	+0.56 (−0.4, +0.9)	0.18	+1.4 (−0.37, +1.9)	0.01	+0.3 (−1.1, +3.1)	0.94	0.23
Current CD4, cells/mm3	+24 (−108, +154)	0.40	−1 (−118, +127)	0.72	+52 (−167, +137)	0.87	+62 (−50, +228)	0.34	0.66
Current CD8, cells/mm3	−23 (−147, +123)	0.84	−59 (−168, +129)	0.86	−56 (−205, +93)	0.61	+36 (−112, +234)	0.67	0.67
CD4/CD8 ratio	+0.05 (−0.05, +0.18)	0.03	+0.03 (−0.7, +0.13)	0.47	+0.06 (−0.06, +0.18)	0.076	+0.05 (−0.01, +2.7)	0.13	0.65
B. Variables at 12 Months
Median (quartile 1, quartile 3)	All Subjects (N=51)		Standard Dose† (N=21)		Moderate Dose‡ (N=18)		High Dose¥ (N=12)		P*
25(OH)D, ng/mL	36.5 (30.2, 43.0)		31.5 (23.8, 36.5)		37.8 (30.6, 42.0)		51.5 (37.6 (27.0, 58.5)		0.001
Body mass index, kg/m2	21.7 (10.0, 25.4)		20.7 (17.8, 23.2)		22.2 (20.0, 28.1)		22.6 (20.4, 24.7)		0.12
Current CD4, cells/mm3	703 (515, 948)		665 (554, 812)		689 (498, 961)		783 (456, 1122)		0.63
Current CD8, cells/mm3	650 (505, 908)		713 (508, 937)		630 (477, 761)		684 (506, 1015)		0.75
CD4/CD8 ratio	1.0 (0.8, 1,5)		0.9 (0.6, 1.3)		1.2 (0.8, 1.5)		1.0 (0.9, 1.6)		0.39

N.B. P-values with bolded font designate those <0.05;

^∘P value within group;

^*P value among the three dosing groups;

^†Standard dose = 18,000 IU given monthly for 12 months (equivalent to 600 IU/daily);

^‡Moderate dose = 60,000 IU given monthly for 12 months (equivalent to 2,000 IU/daily);

^¥High dose = 120,000 IU given monthly for 12 months (equivalent to 4,000 IU/daily).

25(OH)D, 25-hydroxyvitamin D