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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Mol Neurobiol. 2018 Feb 12;55(9):7606–7618. doi: 10.1007/s12035-018-0929-8

Figure 5. ERβ agonist ERB-041 attenuates ER stress-induced brain hyperconnectivity in male mice.

Figure 5

Adult male mice were injected intraperitoneally with tunicamycin (1mg/kg in dimethyl sulfoxide, DMSO), vehicle (DMSO), or ERB-041 (1mg/kg in DMSO, 30 minutes before tunicamycin injection) and tunicamycin (1mg/kg in DMSO). Local field potential (LFP) recordings were performed 12 hours after injection. A) Electrode diagram. REF = reference electrode, mPFC = medial prefrontal cortex electrode, dHIPP = dorsal hippocampal electrode, vHIPP = ventral hippocampal electrode, GND = ground electrode. (B) Coherence v. frequency of mPFC-dorsal HIPP. (C) Coherence in theta (4–12 Hz), beta (15–25 Hz) and gamma (26–70 Hz) bands in mPFC-dorsal HIPP. (D) Coherence v. frequency of mPFC-ventral HIPP. (E) Coherence in theta, beta and gamma bands in mPFC-ventral HIPP. Coherence was determined using values from 3 seconds before and 3 seconds after (for a total of 6 seconds) a novel social interaction with a stranger mouse. *p<0.05, **p<0.01 and ***p<0.001 vs. vehicle; #p<0.05, ##p<0.01 and ###p<0.001 vs. tunicamycin groups. One-way ANOVA. Data are expressed as mean ±s.e.m.