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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Vascul Pharmacol. 2018 Feb 3;114:139–144. doi: 10.1016/j.vph.2018.01.007

Figure 1. Examples of molecular functions of lncRNAs.

Figure 1

A) Xist recruits PRC2 complex to the X chromosome resulting in methylation of H3K27. B) HOTAIR binds to both PRC2 complex and LSD1/CoRest/REST complex modularly to promote methylation of H3K27 and demethylation of H3K4. C) Methylation of H3K27 by PRC2 recruited by asFGFR2 affects the splicing of FGFR2 transcripts transcribed from the opposite strand. D) MALAT1 binds to SR proteins which impact its function as splicing factors in the nucleus. E) H19 is a host transcript for miR-675. F) Linc-MD1 binds to miR-133 and miR-135, affecting their impact on target mRNAs. G) 1/2-sbsRNA binds to mRNAs promoting Staufen1-mediated mRNA decay of the duplexed RNAs.