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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Vascul Pharmacol. 2018 Feb 3;114:139–144. doi: 10.1016/j.vph.2018.01.007

Table 1.

LncRNAs in Diabetic vascular complications

LncRNA Biological Function Mechanism References
ANRIL Atherosclerosis, Hypertension, Diabetes, Retinopathy, Nephropathy Regulation of CDKN2A/B [48]
MIAT Retinal microvascular dysfunction Sponging miR-150-5p [51]
MALAT1 Inflammation in diabetes Upregulation of IL-6 and TNFα [69]
MEG3 Microvascular dysfunction PI3K/Akt signal activation [52]
Lnc-Ang362 Ang II induced VSMC proliferation Expression of miR-221 and miR-222 [42]
E330013P06 Macrophage inflammation in Diabetes Upregulation of IL-6 and Ptgs2 [54]
Lethe Regulation of macrophage ROS production Modulating Nox2 gene expression [56]
Pvt1 ECM accumulation & diabetic nephropathy Regulation of Fn1 and Col4a1 expression [60]
Lnc-MGC Renal fibrosis and early diabetic nephropathy Regulation of EDEM3 expression [62]
Tug1 Mitochondrial energetics of podocytes in diabetes Interaction with PGC-1α [67]