Table 3.

Biodistribution results of ¹⁷⁷Lu-SS-03 and ^99mTc-SS-04 in nude mice bearing HEK293-rsst2 tumour xenografts. Data expressed as %IA/g (percentage of injected activity per gram) and presented as mean ± SD (n = 3–5)

Organs	1 h	4 h	4 h blocking*	24 h
177Lu-SS-03
Blood	0.57 ± 0.04	0.21 ± 0.04	0.07 ± 0.02	0.07 ± 0.04
Heart	0.69 ± 0.12	0.38 ± 0.07	0.11 ± 0.01	0.11 ± 0.04
Liver	3.00 ± 0.66	1.75 ± 0.22	1.04 ± 0.09	0.47 ± 0.07
Spleen	1.51 ± 0.19	1.42 ± 0.77	0.28 ± 0.04	0.33 ± 0.06
Lung	13.24 ± 4.49	6.71 ± 1.37	0.59 ± 0.11	0.74 ± 0.22
Kidney	15.15 ± 1.86	17.04 ± 1.81	20.24 ± 4.30	7.35 ± 1.66
Stomach	48.74 ± 13.11	30.21 ± 4.25	0.37 ± 0.06	6.02 ± 1.40
Intestine	3.13 ± 1.16	2.28 ± 0.31	0.24 ± 0.03	0.27 ± 0.06
Adrenal	3.70 ± 0.63	2.90 ± 0.46	0.06 ± 0.03	1.16 ± 0.46
Pancreas	72.61 ± 13.77	54.49 ± 7.28	0.24 ± 0.07	3.03 ± 0.62
Muscle	0.22 ± 0.06	0.12 ± 0.02	0.06 ± 0.00	0.07 ± 0.02
Bone	4.11 ± 0.53	2.77 ± 1.06	0.12 ± 0.03	1.25 ± 0.16
Tumour	23.64 ± 1.28	31.68 ± 4.00	11.15 ± 1.93	26.32 ± 4.42
99mTc-SS-04
Blood	1.85 ± 0.41	0.22 ± 0.03	0.22 ± 0.01	0.03 ± 0.01
Heart	1.42 ± 0.30	0.25 ± 0.06	0.23 ± 0.02	0.09 ± 0.01
Liver	7.18 ± 0.40	5.13 ± 0.51	4.07 ± 0.65	1.87 ± 0.33
Spleen	2.09 ± 0.34	0.85 ± 0.08	0.63 ± 0.02	0.41 ± 0.11
Lung	15.93 ± 2.69	2.03 ± 0.14	2.00 ± 0.37	0.54 ± 0.10
Kidney	49.82 ± 4.31	25.56 ± 1.01	18.48 ± 3.66	6.31 ± 1.82
Stomach	11.13 ± 2.98	1.99 ± 0.39	0.56 ± 0.03	0.62 ± 0.14
Intestine	2.12 ± 0.57	0.57 ± 0.06	0.42 ± 0.03	0.16 ± 0.02
Adrenal	3.17 ± 0.69	0.99 ± 0.20	0.37 ± 0.10	0.50 ± 0.13
Pancreas	15.58 ± 0.82	1.16 ± 0.86	0.33 ± 0.06	0.31 ± 0.11
Muscle	0.64 ± 0.13	0.12 ± 0.02	0.12 ± 0.02	0.05 ± 0.03
Bone	3.15 ± 0.72	0.92 ± 0.15	0.40 ± 0.01	0.44 ± 0.23
Tumour	47.14 ± 7.23	47.24 ± 7.96	14.17 ± 1.69	32.51 ± 0.78

^*Pre-injection with 20 nmol of unlabelled peptide (SS-03 or SS-04)